Background Elevated plasma levels of alpha‐aminoadipic acid (2‐AAA) have been
associated with the development of type 2 diabetes and atherosclerosis. However, the …

Plasma levels of the metabolite alpha-aminoadipic acid (2-AAA) have been associated with
risk of type 2 diabetes (T2D) and atherosclerosis. However, little is known about the …

Introduction Plasma levels of the metabolite alpha-aminoadipic acid (2-AAA) have been
associated with risk of type 2 diabetes (T2D) and atherosclerosis. However, little is known …

Background and aims The cardiometabolic disease-associated metabolite, alpha-
aminoadipic acid (2-AAA) is formed from the breakdown of the essential dietary amino acid …

Background—The 5-amino acid (AA) signature, including isoleucine, leucine, valine,
tyrosine, and phenylalanine, has been associated with incident diabetes mellitus and insulin …

Background Epidemiological studies demonstrated that multiple amino acids (AAs) were
associated with cardiovascular diseases (CVDs), but whether these associations were …

Insulin resistance is an important clinical feature of metabolic syndrome, which includes
obesity and type 2 diabetes. Increased adipose energy storage in obesity promote insulin …

Arachidonic acid (AA), a major long-chain omega-6 polyunsaturated fatty acid, is associated
with ischemic heart disease (IHD) and stroke. We assessed bi-directional associations of AA …

Background—Omega6 (n6) polyunsaturated fatty acids (PUFAs) and their metabolites are
involved in cell signaling, inflammation, clot formation, and other crucial biological …

Improvements in metabolite-profiling techniques are providing increased breadth of
coverage of the human metabolome and may highlight biomarkers and pathways in …