P. aeruginosa flow-cell biofilms are enhanced by repeated phage treatments but can be eradicated by phage–ciprofloxacin combination: —monitoring the phage–P …

K Henriksen, N Rørbo, ML Rybtke… - Pathogens and …, 2019 - academic.oup.com
Phage therapy has shown promising results in the treatment of Pseudomonas aeruginosa
biofilm infections in animal studies and case reports. The aim of this study was to quantify …

Characterization of Nutrient-Induced Dispersion in Pseudomonas aeruginosa PAO1 Biofilm

K Sauer, MC Cullen, AH Rickard, LAH Zeef… - Journal of …, 2004 - Am Soc Microbiol
The processes associated with early events in biofilm formation have become a major
research focus over the past several years. Events associated with dispersion of cells from …

Biofilms and Planktonic Cells of Pseudomonas aeruginosa Have Similar Resistance to Killing by Antimicrobials

AL Spoering, KIM Lewis - Journal of bacteriology, 2001 - Am Soc Microbiol
Biofilms are considered to be highly resistant to antimicrobial agents. Strictly speaking, this
is not the case—biofilms do not grow in the presence of antimicrobials any better than do …

Pseudomonas aeruginosa Aggregate Formation in an Alginate Bead Model System Exhibits In Vivo-Like Characteristics

M Sønderholm, KN Kragh, K Koren… - Applied and …, 2017 - Am Soc Microbiol
Alginate beads represent a simple and highly reproducible in vitro model system for
diffusion-limited bacterial growth. In this study, alginate beads were inoculated with …

Oxygen Limitation Contributes to Antibiotic Tolerance of Pseudomonas aeruginosa in Biofilms

G Borriello, E Werner, F Roe, AM Kim… - Antimicrobial agents …, 2004 - Am Soc Microbiol
The role of oxygen limitation in protecting Pseudomonas aeruginosa strains growing in
biofilms from killing by antibiotics was investigated in vitro. Bacteria in mature (48-h-old) …

Pseudomonas aeruginosa PAO1 Preferentially Grows as Aggregates in Liquid Batch Cultures and Disperses upon Starvation

D Schleheck, N Barraud, J Klebensberger, JS Webb… - PloS one, 2009 - journals.plos.org
In both natural and artificial environments, bacteria predominantly grow in biofilms, and
bacteria often disperse from biofilms as freely suspended single-cells. In the present study …

Biofilm Matrix and Its Regulation in Pseudomonas aeruginosa

Q Wei, LZ Ma - International journal of molecular sciences, 2013 - mdpi.com
Biofilms are communities of microorganisms embedded in extracellular polymeric
substances (EPS) matrix. Bacteria in biofilms demonstrate distinct features from their free …

Pseudomonas aeruginosa Biofilms

MTT Thi, D Wibowo, BHA Rehm - International journal of molecular …, 2020 - mdpi.com
Pseudomonas aeruginosa is an opportunistic human pathogen causing devastating acute
and chronic infections in individuals with compromised immune systems. Its highly notorious …

Clinical Impact of Antibiotics for the Treatment of Pseudomonas aeruginosa Biofilm Infections

E Olivares, S Badel-Berchoux, C Provot… - Frontiers in …, 2020 - frontiersin.org
Bacterial biofilms are highly recalcitrant to antibiotic therapies due to multiple tolerance
mechanisms. The involvement of Pseudomonas aeruginosa in a wide range of biofilm …

Optimal environmental and culture conditions allow the in vitro coexistence of Pseudomonas aeruginosa and Staphylococcus aureus in stable biofilms

MM Cendra, N Blanco-Cabra, L Pedraz, E Torrents - Scientific reports, 2019 - nature.com
The coexistence between species that occurs in some infections remains hard to achieve in
vitro since bacterial fitness differences eventually lead to a single organism dominating the …