Upstream therapies for management of atrial fibrillation: review of clinical evidence and implications for European Society of Cardiology guidelines. Part I: primary …

I Savelieva, N Kakouros, A Kourliouros, AJ Camm - Europace, 2011 - academic.oup.com
Atrial fibrillation (AF) is associated with significant morbidity and mortality. It is also a
progressive disease secondary to continuous structural remodelling of the atria due to AF …

Research priorities in the secondary prevention of atrial fibrillation: a National Heart, Lung, and Blood Institute virtual workshop report

EJ Benjamin, SM Al‐Khatib, P Desvigne‐Nickens… - 2021 - Am Heart Assoc
There has been sustained focus on the secondary prevention of coronary heart disease and
heart failure; yet, apart from stroke prevention, the evidence base for the secondary …

Why translation from basic discoveries to clinical applications is so difficult for atrial fibrillation and possible approaches to improving it

S Nattel, PT Sager, J Hueser, J Heijman… - Cardiovascular …, 2021 - academic.oup.com
Atrial fibrillation (AF) is the most common sustained clinical arrhythmia, with a lifetime
incidence of up to 37%, and is a major contributor to population morbidity and mortality …

[引用][C] Atherosclerosis and atrial fibrillation–two closely intertwined diseases

K Willeit, S Kiechl - Atherosclerosis, 2014 - atherosclerosis-journal.com
Atrial fibrillation (AF) is among the most common cardiac arrhythmias and its prevalence is
still on the rise [1, 2]. Over the past decades, the proportion of ischemic strokes attributable to …

Translational challenges in atrial fibrillation

J Heijman, JB Guichard, D Dobrev, S Nattel - Circulation research, 2018 - Am Heart Assoc
Atrial fibrillation (AF) is the most common sustained heart rhythm disorder and is associated
with substantial morbidity and mortality. Current treatment options for AF have significant …

Atrial fibrillation: A review of modifiable risk factors and preventive strategies

AS Shamloo, N Dagres, A Arya… - Romanian Journal of …, 2019 - sciendo.com
Atrial fibrillation (AF), as the most common cardiac arrhythmia worldwide, is associated with
increased mortality and morbidity. Successful therapeutic strategies have been introduced …

Atrial fibrillation progression and the importance of early treatment for improving clinical outcomes

MA Gunawardene, S Willems - EP Europace, 2022 - academic.oup.com
Over time, atrial fibrillation (AF) naturally progresses from initially paroxysmal to
persistent/permanent AF caused by structural and electrical remodelling with a complex …

Atrial remodeling, fibrosis, and atrial fibrillation

J Jalife, K Kaur - Trends in cardiovascular medicine, 2015 - Elsevier
The fundamental mechanisms governing the perpetuation of atrial fibrillation (AF), the most
common arrhythmia seen in clinical practice, are poorly understood, which explains in part …

[HTML][HTML] Revisiting antiarrhythmic drug therapy for atrial fibrillation: reviewing lessons learned and redefining therapeutic paradigms

M Geng, A Lin, TP Nguyen - Frontiers in Pharmacology, 2020 - frontiersin.org
Since the clinical use of digitalis as the first pharmacological therapy for atrial fibrillation (AF)
235 years ago in 1785, antiarrhythmic drug therapy has advanced considerably and …

[HTML][HTML] Atrial fibrillation: the current epidemic

CA Morillo, A Banerjee, P Perel, D Wood… - Journal of geriatric …, 2017 - ncbi.nlm.nih.gov
Atrial fibrillation (AF) is the most common arrhythmia diagnosed in clinical practice. The
consequences of AF have been clearly established in multiple large observational cohort …