How tissues are maintained over a lifetime and repaired following injury are fundamental
questions in biology with a disruption to these processes underlying pathologies such as …

The remarkable plasticity of Schwann cells allows them to adopt the Remak (non-myelin)
and myelin phenotypes, which are specialized to meet the needs of small and large …

Peripheral nerve injuries arising from trauma or disease can lead to sensory and motor
deficits and neuropathic pain. Despite the purported ability of the peripheral nerve to self …

The glial cell of the peripheral nervous system (PNS), the Schwann cell (SC), counts among
the most multifaceted cells of the body. During development, SCs secure neuronal survival …

Repair in the peripheral nervous system (PNS) depends upon the plasticity of the
myelinating cells, Schwann cells, and their ability to dedifferentiate, direct axonal regrowth …

The great plasticity of Schwann cells (SCs), the myelinating glia of the peripheral nervous
system (PNS), is a critical feature in the context of peripheral nerve regeneration following …

Peripheral nerves are highly regenerative, in contrast to the poor regenerative capabilities of
the central nervous system (CNS). Here, we show that adult peripheral nerve is a more …

Schwann cells respond to nerve injury by cellular reprogramming that generates cells
specialized for promoting regeneration and repair. These repair cells clear redundant …

Peripheral nerve injuries result in the loss of the motor, sensory and autonomic functions of
the denervated segments of the body. Neurons can regenerate after peripheral axotomy, but …

Nerve injury triggers the conversion of myelin and non‐myelin (Remak) Schwann cells to a
cell phenotype specialized to promote repair. Distal to damage, these repair Schwann cells …