The neurohormone melatonin is involved in the regulation of many physiological functions,
in particular those related to circadian and seasonal rhythms. In mammals, melatonin …

Importance of the field: Increasing clinical evidences suggest that melatonin receptor
agonists can represent a novel therapeutic approach for the treatment of sleep disturbances …

A series of N-(2-phenylbenzofuran-3-yl) ethyl amide and N-(2-arylalkylbenzofuran-3-yl) ethyl
amide derivatives were synthesized and evaluated as melatonin receptor ligands. The …

The design of compounds selective for the MT1 melatonin receptor is still a challenging task
owing to the limited knowledge of the structural features conferring selectivity for the MT1 …

A novel series of melatonin receptor ligands was discovered by opening the cyclic scaffolds
of known classes of high affinity melatonin receptor antagonists, while retaining the …

Introduction: Melatonin is a neurohormone that controls many relevant physiological
processes beyond the control of circadian rhythms. Melatonin's actions are carried out by …

The search for melatonin receptor agonists formed the main part of melatonin medicinal
chemistry programs for the last three decades. In this short review, we summarize the two …

Three-dimensional homology models of human MT1 and MT2 melatonin receptors were
built with the aim to investigate the structure− activity relationships (SARs) of MT2 selective …

Melatonin, an endogenous ligand for melatonin receptor, plays an important role in
modulating various physiological activities through acting on different subtypes MT1, MT2 or …

The three-dimensional quantitative structure− activity relationship comparative molecular
field analysis (3D-QSAR CoMFA) approach was applied to some classes of melatonin (MLT) …