We report the synthesis, binding properties and intrinsic activity at MT1 and MT2 melatonin
receptors of new dimeric melatonin receptor ligands in which two units of the monomeric …

Following our studies of the melatoninergic receptors, we have developed new
tetrahydronaphthalenic derivatives of melatonin that have been tested as selective …

A series of naphthalenic analogues of melatonin were prepared and evaluated as melatonin
receptor MT2 selective ligands. Activity and MT2 selectivity can be modulated with suitable …

Melatonin has a key role in the circadian rhythm relay to periphery organs. Melatonin exerts
its multiple roles mainly through two seven transmembrane domain, G-coupled receptors …

A new series of melatonin (MLT) dimers were obtained by linking together two melatonin
units with a linear alkyl chain through the MLT acetamido group or through a C-2 …

A series of substituted N-[3-(3-methoxyphenyl) propyl] amides were synthesized and their
binding affinities towards human melatonin MT1 and MT2 receptors were evaluated. It was …

A series of phenoxyalkyl and phenylthioalkyl amides were prepared as melatoninergic
ligands. Modulation of affinity of the newly synthesized compound by applying SARs around …

Melatonin MT1 and MT2 receptor ligands have been vigorously explored for the last 4
decades. Inspection of approximately 80 publications in the field revealed that most …

Tetrahydronaphthalenic analogues of melatonin have been synthesized and evaluated as
melatonin receptor ligands. Introduction of a phenyl substituent in the 3-position of the …

The various physiological actions of the neurohormone melatonin are mediated mainly by
two G-protein-coupled MT1 and MT2 receptors. The melatoninergic drugs on the market …