Melatonin MT 1 and MT 2 receptors represent attractive drug targets for the treatment of
various disorders. However, the high conservation of the melatonin binding pocket has …

A series of novel and selective N-[3-(6-benzyloxy-3-methoxyphenyl) propyl] amides has
recently been shown to possess sub-nanomolar range binding affinity to the type 2 …

Numerous diseases have been linked to the malfunction of G-protein coupled receptors (GP-
CRs). Their adequate treatment requires rational design of new high-affinity and high …

Two series of analogues were designed, synthesised and evaluated as potential human
melatonin type 1 and 2 receptor (hMT1 and hMT2) ligands. Their biological effects were …

Melatonin is a neurohormone that has been claimed to be involved in a wide range of
physiological functions. Nevertheless, for most of its effects, the mechanism of action is not …

Models of G protein-coupled melatonin receptor structure suggest that ligand recognition
occurs in a binding pocket formed by transmembrane helices III, V and VII. Constitutively …

The MT2‐selective melatonin receptor ligand UCM765 (N‐(2‐((3‐methoxyphenyl)(phenyl)
amino) ethyl) acetamide), showed interesting sleep inducing, analgesic and anxiolytic …

N-{2-[2-(4-Phenylbutyl)benzofuran-4-yl]cyclopropylmethyl}acetamide: an orally bioavailable
melatonin receptor agonist - ScienceDirect Skip to main contentSkip to article Elsevier logo …

Melatonin is a neurohormone released in a circadian manner with peak levels at night.
Melatonin mediates its effects mainly through G protein-coupled MT1 and MT2 receptors …

NIH3T3 fibroblast cells transfected with the full‐length coding region of the MT2 human
melatonin receptor stably expressed the receptor that is coupled to a pertussis toxin …