Melatonin, N‐acetyl‐5‐methoxytryptamine, an evolutionally old molecule, is produced by the
pineal gland in vertebrates, and it binds with high affinity to melatonin receptors, which are …

It has been difficult, so far, to obtain melatonin analogs possessing high selectivity for the
respective melatonin receptors, mt1 and MT2. In the present work, we report the synthesis …

In order to interpret the effects of melatonin ligands in rats, we need to determine their
activity at the receptor subtype level in the corresponding species. Thus, the rat melatonin …

Pineal hormone melatonin is widely used in the treatment of disorders of circadian rhythms.
The presence of melatonin receptors in various animal tissues motivates the use of this …

Sleep disorders in adults are related to adverse health effects such as reduced quality of life
and increased mortality. About 30–40% of adults are suffering from different sleep disorders …

Melatonin, the pineal gland hormone, is widely distributed in mammalian tissues and exerts
its action via two melatonin receptor sub-types, MT1 and MT2. Melatonin is known to play …

The synthesis of novel melatonin analogues 3a and 4a–c designed as melatonin receptor
ligands is described. Among the newly synthesized ligands, 2-((S)-2-hydroxymethylindolin-1 …

A model of the helical part of the human MT2 melatonin (hMT2) receptor, a member of the G
protein‐coupled receptors superfamily has been generated, based on the structure of …

New 5-acetamido-substituted melatonin derivatives were efficiently synthesized in excellent
yields via Knoevenagel condensation. The relative binding affinity of new synthesized …

Melatonin receptors are seven transmembrane‐spanning proteins belonging to the GPCR
superfamily. In mammals, two melatonin receptor subtypes exist‐MT1 and MT2‐encoded by …