In obesity, accumulation of lipid droplets in skeletal muscle fibers and a shift towards fast
muscle fiber types can both contribute to insulin resistance. However, it is not yet clear how …

Nutrient overload leads to impaired muscle oxidative capacity and insulin sensitivity.
However, comparative analyses of the effects of dietary manipulation on skeletal muscles …

Aim: Data on the skeletal muscle characteristics of patients and animals with lifestyle-related
diseases are limited. We investigated mRNA expression levels and fiber profiles in the …

Aims/hypothesis Although insulin resistance has been associated with accumulations of
specific intramuscular fatty acids and altered subcellular localisation of lipid droplets, these …

OBJECTIVE: To examine skeletal muscle intracellular triglyceride concentration in different
fiber types in relation to obesity. DESIGN: Skeletal muscle fiber type distribution and …

Skeletal muscle is the main tissue of lipid metabolism and accordingly is critical for
homeostasis and energy production; however, the determinants of lipid accumulation in …

The triglyceride content of skeletal muscle samples determined by lipid extraction correlates
with the severity of insulin-resistant glucose metabolism in muscle. To determine whether …

Aims/hypothesis Little is known about the subcellular distribution of lipids in insulin-resistant
skeletal muscle. However, it has recently been suggested that lipid accumulation in the …

Objective To investigate whether differences in muscle fiber types affect early-stage fat
accumulation, under high fat diet challenge in mice. Methods Twelve healthy male C57BL/6 …

Intramyocellular lipid content (IMCL) serves as a good biomarker of skeletal muscle insulin
resistance (IR). However, intracellular fatty acid metabolites [malonyl-CoA, long-chain acyl …