With the increasing prevalence of obesity, research has focused on the molecular
mechanism (s) linking obesity and skeletal muscle insulin resistance. Metabolic alterations …

The present study aimed to determine relationships between intramyocellular lipid and
biochemical profiles or muscle strength in elderly (n= 15; mean age, 71 years) and young …

Insulin resistance of peripheral muscle is implicated in the etiology of metabolic syndrome in
obesity. Although accumulation of glycerolipids, such as triacylglycerol and diacylglycerol …

Skeletal muscle is the major site for insulin-stimulated glucose disposal, and muscle insulin
resistance confers many negative health outcomes. Muscle is composed of multiple fiber …

Aims/hypothesis The mechanisms for diet-induced intramyocellular lipid accumulation and
its association with insulin resistance remain contentious. In a detailed time-course study in …

OBJECTIVE: To investigate whether young rats respond to high-fat feeding through changes
in energy efficiency and fuel partitioning at the level of skeletal muscle, to avoid obesity …

OBJECTIVE We tested the primary hypotheses that sphingolipid and diacylglycerol (DAG)
content is higher within insulin-resistant muscle and that the association between …

Inter-individual variability in weight gain and loss under energy surfeit and deficit conditions,
respectively, are well recognized but poorly understood phenomena. We documented …

The skeletal muscle is the largest organ in the body. It plays a particularly pivotal role in
glucose homeostasis, as it can account for up to 40% of the body and for up to 80%–90% of …

In addition to obesity, many factors, including the distribution of body fat, contribute to the
development of insulin resistance and type 2 diabetes mellitus (T2DM). Lipid contained …