Background Elevated fatty acids contribute to the development of type 2 diabetes and affect
skeletal muscle insulin sensitivity. Since elevated intramuscular lipids and insulin resistance …

Intramyocellular triglyceride (imcTG) content in skeletal muscle is abnormally high in lipid
oversupply models in obesity, type 2 diabetes (T2D) and other metabolically diseased …

The investigation of intramyocellular lipids (IMCLs) with proton MR spectroscopy (1H‐MRS)
in humans has recently received increasing attention. IMCL levels correlate with insulin …

Different mouse strains exhibit variation in their inherent propensities to develop metabolic
disease. We recently showed that C57BL6, 129X1, DBA/2 and FVB/N mice are all …

OBJECTIVE Chronic exercise and obesity both increase intramyocellular triglycerides
(IMTGs) despite having opposing effects on insulin sensitivity. We hypothesized that …

Insulin resistance in type 2 diabetes (T2D) is associated with intramuscular lipid (IMCL)
accumulation. To determine whether impaired lipid oxidation is involved in IMCL …

The present article addresses the hypothesis that disturbances in skeletal muscle fatty acid
handling in abdominal obesity and type 2 diabetes mellitus may play a role in the aetiology …

Background Insulin resistance is associated with the higher content of intermuscular
adipose tissue (IMAT) and the saturation of intramyocellular lipid (IMCL), but a paucity of …

Comparing energy metabolism in human skeletal muscle and primary skeletal muscle cells
in obesity, while focusing on glucose and fatty acid metabolism, shows many common …

The etiology of insulin resistance in Type 1 Diabetes (T1D) is unknown, however it affects
approximately 20% of T1D patients. Intramyocellular lipids (IMCL) have been identified as a …