Amiodarone is widely used to treat cardiac arrhythmias and is very effective in preventing
these disorders. However, its use is limited by a wide range of adverse effects, mainly …

Background and purpose: Tissue deposits of the anti‐arrhythmic drug amiodarone are a
major source of side effects (skin discoloration, etc.). We addressed the mechanism of the …

Amiodarone (AMIO), a potent antiarrhythmic drug, is clinically widely used despite its
frequent side effects after chronic administration. These side effects coincide with an …

Amiodarone (AD) is a highly efficient antiarrhythmic drug with potentially serious side effects.
Severe pulmonary toxicity is reported in patients receiving AD even at low doses and may …

Amiodarone (AD) is an iodinated benzofuran derivative, especially known for its
antiarrhythmic properties. It exerts serious side‐effects even in patients receiving low doses …

Amiodarone, an antiarrhythmic drug toxic toward the lung, is metabolized through sequential
modifications of the diethylaminoethoxy group to mono-N-desethylamiodarone (MDEA), di-N …

Abstract Treatment with the iodine-containing antiarrhythmic drug, amiodarone, can cause
pulmonary toxicity. Alveolar macrophages are particularly susceptible to formation of lipid …

Amiodarone (AD) is gaining support as a first-line antiarrhythmic drug despite its potentially
fatal pulmonary toxicity involving inflammation and fibrosis. We previously reported a model …

Amiodarone is a well-known antiarrhythmic drug with side effects including
phospholipidosis. However, it is not clear how amiodarone and its metabolites are localized …

Amiodarone (AMI) is a potent antiarrhythmic agent; however, its clinical use is limited due to
numerous side effects. In order to investigate the structure–cytotoxicity relationship, AMI …