Various mechanisms are involved in drug hepatotoxicity including reactive intermediates,
steatosis, phospholipidosis, mitochondrial dysfunction, etc. Although 3D cultured …

Amiodarone (AM) is a potent antidysrhythmic agent that is limited in clinical use by its
adverse effects, including potentially life-threatening AM-induced pulmonary toxicity (AIPT) …

Background: Amiodarone is underutilized due to significant off-target toxicities. We
hypothesized that targeted delivery to the heart would lead to the lowering of the dose by …

Patients treated with amiodarone accumulate lysobisphosphatidic acid (LBPA), also known
as bis (monoacylglycero) phosphate, in airway secretions and develop in different tissues …

Amiodarone-induced Phospholipidosis in Rat Alveolar Macrophages Page 1 Amiodarone-induced
Phospholipidosis in Rat Alveolar Macrophages1 - 3 MARK J. REASOR, CANDACE L. OGLE …

Amiodarone (AM) is an efficacious antidysrhythmic agent that is limited clinically by
numerous adverse effects. Of greatest concern is AM-induced pulmonary toxicity (AIPT) due …

Amiodarone is a potent antianginal and antiarrhythmic drug which affects the lipid dynamics.
The influence of amiodarone ionization on the lipid transition temperature and enthalpy …

Associated with amiodarone (AM) therapy is pneumonitis, which may progress to life-
threatening pulmonary fibrosis. Although the etiology of amiodarone-induced pulmonary …

A rapid and sensitive high-performance liquid chromatography (HPLC) method was
developed and validated in rat plasma and tissue (heart, liver, kidney and lung) …

Although amiodarone is a highly efficacious antidysrhythmic agent, the drug produces
numerous adverse effects. The most critical of these is pulmonary toxicity because of the …