The difficulty in mimicking nervous system complexity and cell–cell interactions as well as
the lack of kinetics information has limited the use of in vitro neurotoxicity data. Here, we …

MATERIALS AND METHODS Equipment The IR spectrum was recorded using a Hitachi 270-
30 spectrometer (Tokyo, Japan). A proton nuclear magnetic resonance (1H-NMR) spectrum …

A rat model of amiodarone-induced pulmonary toxicity is described. The rats were fed, by
gavage, 175 mg/kg/day of amiodarone hydrochloride suspended in methyl cellulose …

When administered to humans and animals, the iodine-containing drug amiodarone can
cause pulmonary toxicity. As part of the pulmonary response to amiodarone, the drug and its …

Study objective To characterize the inflammation observed in amiodarone-induced
pneumonitis. Design The density of inflammatory cells in BAL fluid (BALF) and lung …

Amiodarone, bi-iodinated benzofuran derivative, is one of the most frequently prescribed
and efficacious antiarrhythmic drugs. Despite its low incidence, amiodarone-induced …

To determine whether a hypersensitivity reaction played a role in amiodarone-induced
pulmonary inflammation and affected humoral immunity, we examined pulmonary …

Amiodarone (AM) is a potent and efficacious antidysrhythmic agent that can cause
potentially life-threatening pulmonary fibrosis. Vitamin E has been demonstrated to …

Toinvestigate the hypotheses that amiodarone-induced pulmonary inflammation may be
related to direct drug toxicity, groups of 10or more Wistar rats were fed amiodarone by …

Since recent in vivo evidence suggests that the benzofuran antiarrhythmic drug amiodarone
has a direct toxic effect on the human thyroid gland, we have investigated the effects of both …