Amiodarone-induced lymphocyte toxicity and mitochondrial function

SU Yasuda, EA Sausville, JB Hutchins… - Journal of …, 1996 - journals.lww.com
Amiodarone is one of the most effective anti-arrhythmic drugs available. However, its use is
often limited by potentially life-threatening toxicities, including hepatotoxicity and pulmonary …

Amiodarone pulmonary toxicity. Clinical, cytologic and ultrastructural findings.

B Stein, GS Zaatari, JR Pine - Acta cytologica, 1987 - europepmc.org
Amiodarone, a new antiarrhythmic drug, may produce severe and potentially lethal
pulmonary toxicity. A case is presented of a patient on amiodarone therapy who presented …

The role of free radicals in the pathogenesis of amiodarone toxicity

A Vereckei, A Blazovics, I Gyorgy… - Journal of …, 1993 - Wiley Online Library
Free Radicals and Amiodarone Toxicity. Introduction: In vitro and in vivo studies were
performed to elucidate the pathogenesis of amiodarone toxicity. Methods and Results: Rats …

Amiodarone pulmonary toxicity: functional and ultrastructural evaluation.

FL Liu, RD Cohen, E Downar, JW Butany, JD Edelson… - Thorax, 1986 - thorax.bmj.com
Pulmonary function, chest radiographic appearances, and the cellular composition of
bronchoalveolar lavage fluid were assessed in 13 patients who were receiving amiodarone …

[引用][C] Measurement of amiodarone

DW Holt, GCA Storey - Amiodarone and Arrhythmias, 1983 - Pergamon Press Oxford

Cytotoxicity effects of amiodarone on cultured cells

E El Golli-Bennour, A Bouslimi, O Zouaoui… - Experimental and …, 2012 - Elsevier
Amiodarone is a potent anti-arrhythmic drug used for the treatment of cardiac arrhythmias.
Although, the effects of amiodarone are well characterized on post-ischemic heart and …

Aryl radical involvement in amiodarone-induced pulmonary toxicity: investigation of protection by spin-trapping nitrones

AC Nicolescu, JL Comeau, BC Hill, LL Bedard… - Toxicology and applied …, 2007 - Elsevier
Amiodarone (AM), an antidysrrhythmic drug, can produce serious adverse effects, including
potentially fatal AM-induced pulmonary toxicity (AIPT). AM-induced cytotoxicity and …

Amiodarone-induced pulmonary fibrosis in Fischer 344 rats

PG Reinhart, YL Lai, CG Gairola - Toxicology, 1996 - Elsevier
Amiodarone is a potent antiarrhythmic agent with a number of side-effects, the most serious
being the development of pulmonary toxicity. The purpose of the study was to determine if a …

Amiodarone pulmonary toxicity: biochemical evidence for a cellular phospholipidosis in the bronchoalveolar lavage of human subjects.

WJ Martin, JE Standing - Journal of Pharmacology and Experimental …, 1988 - ASPET
Amiodarone pulmonary toxicity represents an example of a life-threatening adverse drug
reaction. Our study examined 10 subjects with amiodarone pulmonary toxicity by …

Single-dose kinetics of tissue distribution, excretion and metabolism of amiodarone in rats.

PA Wyss, MJ Moor, MH Bickel - Journal of Pharmacology and Experimental …, 1990 - ASPET
In order to better understand the pharmacokinetic differences between acute and chronic
regimens of the basic lipophilic antiarrhythmic, amiodarone (AM), a mass-balanced single …