'Foamy'alveolar macrophages (FAM) observed in nonclinical toxicology studies during
inhaled drug development may indicate drug-induced phospholipidosis, but can also derive …

Amiodarone is an antiarrhythmic drug with numerous side effects, the most serious being the
development of pulmonary toxicity. We have previously reported that a single intratra cheal …

It has been reported that amiodarone induces disorders of alveolar macrophages and pul
monary fibrosis, but the mechanism is not well-understood. This study was performed to …

The effectiveness of amiodarone in the treatment of cardiac arrhythmias is limited due to the
development of pulmonary toxicity. Although the biochemical and morphologic …

In these studies we examined the kinetics of amiodarone (Am) uptake and efflux in/from the
lung, and the influence of other amphiphilics on these processes. We used single-pass …

The mechanism of amiodarone-induced pulmonary toxicity is unknown. Two cases of
amiodarone pulmonary toxicity are presented in which abnormal inclusion bodies …

Amiodarone is a potent antiarrhythmic drug and displays substantial liver toxicity in humans.
It has previously been demonstrated that amiodarone and its metabolite …

Toinvestigate the hypotheses that amiodarone-induced pulmonary inflammation may be
related to direct drug toxicity, groups of 10or more Wistar rats were fed amiodarone by …

The limited value of in vitro toxicity data for the in vivo extrapolation has been often attributed
to the lack of kinetic data. Here the in vitro kinetics of amiodarone (AMI) and its mono-N …

Cardiac and extra-cardiac side effects of common antiarrhythmic agents might be related to
drug-induced mitochondrial dysfunction. Supratherapeutic doses of amiodarone have been …