Earlier work in this laboratory showed that amiodarone induces apoptosis in alveolar
epithelial cells by a mechanism inhibitable by angiotensin system antagonists. A variety of …

Amiodarone can cause pulmonary toxicity along with an increase in phospholipid in
macrophages, lymphocytes, and other cell types. Phospholipid accumulates because …

Four groups of rats were given amiodarone chronically at 25, 37ṁ5, 50, 75 mg kg− 1/12 h
for 3 weeks; on day 21 the animals were killed and blood, plasma, heart, lung, liver and fat …

Although the efficacy of amiodarone in the treatment of drug refractory cardiac arrhythmias is
firmly established, the same cannot be said for the dosage. Amiodarone has been described …

A high-performance liquid chromatographic (HPLC) method for the measurement of
amiodarone (AM) and its metabolite (s) in serum and tissues was developed. The method …

The use of the antiarrythmic drug amiodarone (AD) has been limited by the propensity of the
drug to cause severe lung damage. AD has been shown to produce a transient pulmonary …

Amiodarone is a benzofuran derivative used to treat arrhythmias, but its use is limited by
adverse reactions. There is evidence that some of the severe adverse reactions such as liver …

Amiodarone (AMI) is a potent antiarrhythmic drug, but its metabolism has not yet been fully
documented. Mono-N-desethylamiodarone (MDEA) is its only known metabolite. Our …

This study was designed to determine serum and tissue concentra-tions of amiodarone and
its metabolite desethylamiodarone after chronic amiodarone administration in rabbits …

Amiodarone (AMI) is a potent antiarrhythmic drug. In vivo and in vitro, AMI is biotransformed
to mono-N-desethylamiodarone (MDEA). Recently, it was observed that MDEA was further …