[HTML][HTML] Association of SMAD4 mutation with patient demographics, tumor characteristics, and clinical outcomes in colorectal cancer
SMAD4 is an essential mediator in the transforming growth factor-β pathway. Sporadic
mutations of SMAD4 are present in 2.1–20.0% of colorectal cancers (CRCs) but data are …
mutations of SMAD4 are present in 2.1–20.0% of colorectal cancers (CRCs) but data are …
[HTML][HTML] Association of overexpression of TIF1γ with colorectal carcinogenesis and advanced colorectal adenocarcinoma
S Jain, S Singhal, F Francis, C Hajdu… - World Journal of …, 2011 - ncbi.nlm.nih.gov
AIM: To determine the expression and clinical significance of transcriptional intermediary
factor 1 gamma (TIF1γ), Smad4 and transforming growth factor-beta (TGFβR) across a …
factor 1 gamma (TIF1γ), Smad4 and transforming growth factor-beta (TGFβR) across a …
Impaired transforming growth factor β signalling in Barrett's carcinogenesis due to frequent SMAD4 inactivation
Background and aims: Transforming growth factor β (TGF-β) is frequently involved in
gastrointestinal carcinogenesis although its contribution to oesophageal adenocarcinoma …
gastrointestinal carcinogenesis although its contribution to oesophageal adenocarcinoma …
SMAD2, SMAD3 and SMAD4 Mutations in Colorectal Cancer
Activation of the canonical TGF-β signaling pathway provides growth inhibitory signals in the
normal intestinal epithelium. Colorectal cancers (CRCs) frequently harbor somatic mutations …
normal intestinal epithelium. Colorectal cancers (CRCs) frequently harbor somatic mutations …
Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice
The tumor suppressor SMAD4, also known as DPC4, deleted in pancreatic cancer, is a
central mediator of TGF-β signaling. It was previously shown that mice homozygous for a …
central mediator of TGF-β signaling. It was previously shown that mice homozygous for a …
Contribution of transforming growth factor-β signaling to intestinal cancer development
NM Muñoz - 2006 - ir.vanderbilt.edu
Transforming Growth Factor-β (TGF-β) is a cytokine involved in the regulation of multiple
cellular responses, and it is accepted that the TGF-β signaling pathway is implicated in both …
cellular responses, and it is accepted that the TGF-β signaling pathway is implicated in both …
Smad2 and Smad3 phosphorylated at both linker and COOH-terminal regions transmit malignant TGF-β signal in later stages of human colorectal cancer
K Matsuzaki, C Kitano, M Murata, G Sekimoto… - Cancer research, 2009 - AACR
Transforming growth factor (TGF)-β initially inhibits growth of mature epithelial cells. Later,
however, autocrine TGF-β signaling acts in concert with the Ras pathway to induce a …
however, autocrine TGF-β signaling acts in concert with the Ras pathway to induce a …
SMAD7 and SMAD4 expression in colorectal cancer progression and therapy response
Inhibitory SMAD7 and common mediator SMAD4 play crucial roles in SMAD-dependent TGF-
β signaling that is often disrupted in colorectal cancer (CRC). This study aimed to profile the …
β signaling that is often disrupted in colorectal cancer (CRC). This study aimed to profile the …
[HTML][HTML] Correlation between SMADs and Colorectal Cancer expression, prognosis, and Immune infiltrates
N Ding, H Luo, T Zhang, T Peng, Y Yao… - International Journal of …, 2023 - hindawi.com
Background. In recent years, the incidence and mortality of colorectal cancer (CRC) are
increasing, and the 5-year survival rate of advanced metastatic CRC is poor. Small mothers …
increasing, and the 5-year survival rate of advanced metastatic CRC is poor. Small mothers …