[PDF][PDF] Combating an intrinsic antibiotic resistance mechanism by interfering with small RNA regulation of an outer membrane porin

A Batresian - 2021 - scholarworks.calstate.edu
The discovery of novel antibiotics has not kept pace with the growing threat of bacterial
resistance. Bacteria have remarkable genetic plasticity that allows them to respond to a wide …

[HTML][HTML] Distinct roles of outer membrane porins in antibiotic resistance and membrane integrity in Escherichia coli

U Choi, CR Lee - Frontiers in microbiology, 2019 - frontiersin.org
A defining characteristic of Gram-negative bacteria is the presence of an outer membrane,
which functions as an additional barrier inhibiting the penetration of toxic chemicals, such as …

Outer membrane porins contribute to antimicrobial resistance in Gram-negative bacteria

G Zhou, Q Wang, Y Wang, X Wen, H Peng, R Peng… - Microorganisms, 2023 - mdpi.com
Gram-negative bacteria depend on their cell membranes for survival and environmental
adaptation. They contain two membranes, one of which is the outer membrane (OM), which …

Amelioration of the fitness costs of antibiotic resistance due to reduced outer membrane permeability by upregulation of alternative porins

M Knopp, DI Andersson - Molecular biology and evolution, 2015 - academic.oup.com
The fitness cost of antibiotic resistance is a key parameter in determining the evolutionary
success of resistant bacteria. Studies of the effect of antibiotic resistance on bacterial fitness …

Superfolder GFP reporters validate diverse new mRNA targets of the classic porin regulator, MicF RNA

CP Corcoran, D Podkaminski, K Papenfort… - Molecular …, 2012 - Wiley Online Library
MicF is a textbook example of a small regulatory RNA (sRNA) that acts on a trans‐encoded
target mRNA through imperfect base pairing. Discovery of MicF as a post‐transcriptional …

Dual Regulation of the Small RNA MicC and the Quiescent Porin OmpN in Response to Antibiotic Stress in Escherichia coli

S Dam, JM Pagès, M Masi - Antibiotics, 2017 - mdpi.com
Antibiotic resistant Gram-negative bacteria are a serious threat for public health. The
permeation of antibiotics through their outer membrane is largely dependent on porin …

MicF: an antisense RNA gene involved in response of Escherichia coli to global stress factors

N Delihas, S Forst - Journal of molecular biology, 2001 - Elsevier
The micF gene is a stress response gene found in Escherichia coli and related bacteria that
post-transcriptionally controls expression of the outer membrane porin gene ompF. The micF …

Investigation of gating in outer membrane porins provides new perspectives on antibiotic resistance mechanisms

AK Vasan, N Haloi, RJ Ulrich, ME Metcalf, PC Wen… - bioRxiv, 2021 - biorxiv.org
Gram-negative bacteria pose a serious public health concern, primarily due to a higher
frequency of antibiotic resistance conferred to them as a result of low permeability of their …

A role for the Escherichia coli H‐NS‐like protein StpA in OmpF porin expression through modulation of micF RNA stability

P Deighan, A Free, CJ Dorman - Molecular microbiology, 2000 - Wiley Online Library
When a wild‐type strain of Escherichia coli and its stpA, hns and stpA hns mutant derivatives
were compared by two‐dimensional protein gel electrophoresis, the levels of expression of …

Role of internal loop dynamics in antibiotic permeability of outer membrane porins

AK Vasan, N Haloi, RJ Ulrich… - Proceedings of the …, 2022 - National Acad Sciences
Gram-negative bacteria pose a serious public health concern due to resistance to many
antibiotics, caused by the low permeability of their outer membrane (OM). Effective …