Bacterial resistance represents a growing threat to human and animal health worldwide. In
Europe, it is responsible for around 25,000 deaths per year; and the medical costs …

Multi-drug resistant (MDR) bacteria are an increasingly serious threat to global public health.
In the last decades, many studies showed that general outer membrane porins (OMPs) from …

Gram-negative bacteria are problematic for antibiotic development due to the low
permeability of their cell envelopes. To rationally design new antibiotics capable of …

Previous studies have shown that E. coli B23 cells pretreated with a sub-inhibitory
concentration of the aminoglycoside kanamycin develop short term (1.5 hour) resistance …

Although some outer membrane (OM) proteins involved in antibiotic resistance have been
previously reported, the OM proteins regulating chlortetracycline (CTC) resistance are …

The environmental pollution caused by antibiotics is becoming more and more serious.
Outer membrane proteins (OMPs) play key roles in the resistance of bacteria to antibiotics …

The development of short peptides that specifically bind to higher-order structures of
ribosomal RNA is one promising way to address the problem of antibiotic resistance …

Disruption of the outer membrane (OM) barrier allows for the entry of otherwise inactive
antimicrobials into Gram-negative pathogens. Numerous efforts to implement this approach …

Gram-negative bacteria cause the majority of highly drug-resistant bacterial infections. To
cross the outer membrane of the complex Gram-negative cell envelope, antibiotics permeate …