Age‐associated diseases are rising to pandemic proportions, exposing the need for efficient
and low‐cost methods to tackle these maladies at symptomatic, behavioral, metabolic, and …

BACKGROUND Reduced caloric intake without malnutrition is the oldest known life span–
extending intervention. Laboratory studies throughout the 20th century established and …

Genetic and pharmacological interventions have successfully extended healthspan and
lifespan in animals, but their genetic interventions are not appropriate options for human …

An epidemic of obesity has affected large portions of the world, increasing the risk of
developing many different age-associated diseases, including cancer, cardiovascular …

The global human population has recently experienced an increase in life expectancy with a
mounting concern about the steady rise in the incidence of age-associated chronic diseases …

Dietary restriction (DR) decreases body weight, improves health, and extends lifespan. DR
can be achieved by controlling how much and/or when food is provided, as well as by …

Improvements in health care have increased human life expectancy in recent decades, and
the elderly population is thus increasing in most developed countries. Unfortunately this still …

Caloric restriction is the most effective and reproducible dietary intervention known to
regulate aging and increase the healthy lifespan in various model organisms, ranging from …

The human diet and dietary patterns are closely linked to the health status. High-calorie
Western-style diets have increasingly come under scrutiny as their caloric load and …

Calorie restriction (CR) promotes healthy ageing in diverse species. Recently, it has been
shown that fasting for a portion of each day has metabolic benefits and promotes lifespan …