[PDF][PDF] Specific binding to differentially-expressed human CEACAMs determines the outcome of Neisseria gonorrhoeae infections along the female reproductive tract

EA Islam, VC Anipindi, I Francis… - Infect …, 2018 - researchgate.net
The gonococcal Opa proteins are an antigenically variable family of surface adhesins that
bind 27 human CEACAM1, CEACAM3, CEACAM5 and/or CEACAM6, cell surface …

Specific binding to differentially expressed human carcinoembryonic antigen-related cell adhesion molecules determines the outcome of Neisseria gonorrhoeae …

EA Islam, VC Anipindi, I Francis… - Infection and …, 2018 - Am Soc Microbiol
The gonococcal Opa proteins are an antigenically variable family of surface adhesins that
bind human carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) …

Selection for a CEACAM receptor-specific binding phenotype during Neisseria gonorrhoeae infection of the human genital tract

A Sintsova, H Wong, KS MacDonald, R Kaul… - Infection and …, 2015 - Am Soc Microbiol
Infections by Neisseria gonorrhoeae are increasingly common, are often caused by
antibiotic-resistant strains, and can result in serious and lasting sequelae, prompting the …

Defining the roles of human carcinoembryonic antigen-related cellular adhesion molecules during neutrophil responses to Neisseria gonorrhoeae

H Sarantis, SD Gray-Owen - Infection and immunity, 2012 - Am Soc Microbiol
Symptomatic infection of humans with Neisseria gonorrhoeae is characterized by a
neutrophil-rich cervical or urethral exudate, suggesting that neutrophils are important both …

CEACAM is not necessary for Neisseria gonorrhoeae to adhere to and invade female genital epithelial cells

KV Swanson, GA Jarvis, GF Brooks… - Cellular …, 2001 - Wiley Online Library
Neisseria gonorrhoeae has a repertoire of up to 11 opacity‐associated (Opa) proteins that
are adhesins. Most Opa proteins adhere to CEACAM antigens and when CEACAM …

Innate recognition by neutrophil granulocytes differs between Neisseria gonorrhoeae strains causing local or disseminating infections

A Roth, C Mattheis, P Muenzner, M Unemo… - Infection and …, 2013 - Am Soc Microbiol
Members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family
serve as cellular receptors for Neisseria gonorrhoeae. More specifically, neisserial colony …

Imaging Flow Cytometry Analysis of CEACAM Binding to Opa‐Expressing Neisseria gonorrhoeae

LM Werner, A Palmer, A Smirnov… - Cytometry Part …, 2020 - Wiley Online Library
Human carcinoembryonic antigen‐related cell adhesion molecules (CEACAMs) are a family
of receptors that mediate intercellular interactions. Pathogenic bacteria have ligands that …

In vitro analysis of matched isolates from localized and disseminated gonococcal infections suggests that opa expression impacts clinical outcome

CT Wu, PW Huang, CH Lin, DC Stein, W Song… - Pathogens, 2022 - mdpi.com
Gonorrhea is the second most common sexually transmitted infection, which is primarily
localized but can be disseminated systemically. The mechanisms by which a localized …

CEACAM1 dynamics during Neisseria gonorrhoeae suppression of CD4+ T lymphocyte activation

HSW Lee, MA Ostrowski… - The Journal of …, 2008 - journals.aai.org
Neisseria gonorrhoeae colony opacity-associated (Opa) proteins bind to human
carcinoembryonic antigen cellular adhesion molecules (CEACAM) found on host cells …

Nuclear Factor-κB Directs Carcinoembryonic Antigen-related Cellular Adhesion Molecule 1 Receptor Expression inNeisseria gonorrhoeae-infected Epithelial Cells

P Muenzner, O Billker, TF Meyer… - Journal of Biological …, 2002 - ASBMB
The human-specific pathogen Neisseria gonorrhoeae expresses opacity-associated (Opa)
protein adhesins that bind to various members of the carcinoembryonic antigen-related …