Oxygent™, a perfluorochemical-based oxygen therapeutic for surgical patients

PE Keipert - Blood Substitutes and Oxygen Biotherapeutics, 2022 - Springer
For many decades, scientists have actively pursued development of 'artificial blood'–seeking
a product that is safe, universally compatible with all blood types, and readily available for …

Use of Oxygent™, A Perfluorochemical-Based Oxygen Carrier, as An Alternative to Intraoperative Blood Transfusion

PE Keipert - Artificial Cells, Blood Substitutes, and Biotechnology, 1995 - Taylor & Francis
Oxygent™ is a stable concentrated perfluorochemical (PFC) emulsion being developed for
use as a temporary oxygen carrier. In this application, PFC emulsions can be used to …

Oxygen therapeutics (“blood substitutes”) where are they, and what can we expect?

PE Keipert - Oxygen Transport to Tissue Xxv, 2003 - Springer
For almost a century, scientists have been pursuing the development of “artificial blood”—
seeking a product that would be safe, universally compatible with all blood types, and …

[PDF][PDF] Update on perfluorocarbon-based oxygen delivery systems

JG Riess, PE Keipert - Blood Substitutes: Present and Future …, 1998 - ndl.ethernet.edu.et
Few options are given to the critical care physician to combat tissue hypoxia and its
consequences. Once circulating volume has been restored and the patient has been given …

Fluorinated blood substitutes and oxygen carriers

KC Lowe - Journal of Fluorine Chemistry, 2001 - Elsevier
Perfluorochemicals (PFCs) are highly fluorinated, inert organic compounds that can dissolve
large volumes of O2 and other respiratory gases. PFCs are unreactive in the body and …

Oxygen therapeutics: perfluorocarbons and blood substitute safety

CS Cohn, MM Cushing - Critical care clinics, 2009 - Elsevier
Current demands over the blood supply in developed and developing nations will
compound over time. Red cell substitutes have a promising value proposition for transfusion …

Perfluorinated blood substitutes and artificial oxygen carriers

KC Lowe - Blood reviews, 1999 - Elsevier
Blood transfusion is a remarkably safe, routine clinical procedure. However, the need for
sophisticated blood processing, storage and cross-matching, coupled with increasing …

Alternative oxygen therapeutics: products, status of clinical trials, and future prospects.

RM Winslow - Current Hematology Reports, 2003 - europepmc.org
Alternative oxygen therapeutics are oxygen carriers that can potentially replace red blood
cell transfusion in clinical instances in which banked blood is unavailable or unsafe. Most of …

Use of a PFC-based oxygen carrier to lower the transfusion trigger in a canine model of hemodilution and surgical blood loss

S Batra, PE Keipert, JD Bradley, NS Faithfull… - Oxygen Transport to …, 1997 - Springer
Perfluorochemical (PFC) emulsions are inert compounds that demonstrate a high solubility
for gases, and are being developed as temporary intravenous oxygen carriers for …

Blood substitutes and oxygen therapeutics: a review

JS Jahr, NR Guinn, DR Lowery… - Anesthesia & …, 2021 - journals.lww.com
Despite the exhaustive search for an acceptable substitute to erythrocyte transfusion, neither
chemical-based products such as perfluorocarbons nor hemoglobin-based oxygen carriers …