Therapeutic Potential of Protein Kinases and Their Downstream Targets Following Traumatic Cervical Spinal Cord Injury

MM Zavvarian - 2023 - search.proquest.com
Despite recent advances in the management and characterization of traumatic spinal cord
injury (SCI), the current therapeutic options for patients remain limited. The SCI-induced …

The protein kinase inhibitor midostaurin improves functional neurological recovery and attenuates inflammatory changes following traumatic cervical spinal cord injury

MM Zavvarian, J Hong, M Khazaei, JCT Chio, J Wang… - Biomolecules, 2021 - mdpi.com
Traumatic spinal cord injury (SCI) impairs neuronal function and introduces a complex
cascade of secondary pathologies that limit recovery. Despite decades of preclinical and …

Translational Relevance of Secondary Intracellular Signaling Cascades Following Traumatic Spinal Cord Injury

MM Zavvarian, AD Modi, S Sadat, J Hong… - International Journal of …, 2024 - mdpi.com
Traumatic spinal cord injury (SCI) is a life-threatening and life-altering condition that results
in debilitating sensorimotor and autonomic impairments. Despite significant advances in the …

[PDF][PDF] Novel insights into pathophysiology and emerging therapeutic opportunities

N Forgione, MG Fehlings - 2013 - Taylor & Francis
Spinal cord injury (SCI) is a devastating event, with profound social, economic and
emotional repercussions for patients. It is estimated that the worldwide incidence of SCI is …

Molecular insights of the injured lesions of rat spinal cords: Inflammation, apoptosis, and cell survival

YH Ahn, YB Yeon, G Lee, KK Mee, SK Kang - Biochemical and biophysical …, 2006 - Elsevier
Spinal cord injury (SCI) is a devastating neurologic injury with functional deficits. In the acute
phase, which starts at the moment of the injury and extends over the first few days …

Pathophysiology of spinal cord injury

LD Hachem, MG Fehlings - Neurosurgery Clinics, 2021 - neurosurgery.theclinics.com
Spinal cord injury (SCI) triggers a complex cascade of molecular and chemical events that
leads to progressive cell loss and tissue damage. 1, 2 Nearly a century of fundamental basic …

Traumatic spinal cord injury: an overview of pathophysiology, models and acute injury mechanisms

A Alizadeh, SM Dyck, S Karimi-Abdolrezaee - Frontiers in neurology, 2019 - frontiersin.org
Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial
socioeconomic implications for patients and their care-givers. Recent advances in medical …

Stress-activated protein kinases in spinal cord injury: focus on roles of p38

Y Kasuya, H Umezawa, M Hatano - International Journal of Molecular …, 2018 - mdpi.com
Spinal cord injury (SCI) consists of three phases—acute, secondary, and chronic damages—
and limiting the development of secondary damage possibly improves functional recovery …

Emerging molecular therapeutic targets for spinal cord injury

S Wang, GM Smith, ME Selzer, S Li - Expert opinion on therapeutic …, 2019 - Taylor & Francis
Introduction: Spinal cord injury (SCI) is a complicated and devastating neurological disorder.
Patients with SCI usually have dramatically reduced quality of life. In recent years, numerous …

[HTML][HTML] Advances of the MAPK pathway in the treatment of spinal cord injury

S Huang, Y Zhang, H Shu, W Liu, X Zhou… - CNS Neuroscience & …, 2024 - ncbi.nlm.nih.gov
Spinal cord injury (SCI) represents a complex pathology within the central nervous system
(CNS), leading to severe sensory and motor impairments. It activates various signaling …