Gene networks have yielded numerous neurobiological insights, yet an integrated view
across brain regions is lacking. We leverage RNA sequencing in 864 samples representing …

Background To explore the domain-general risk factor of early-life social stress in mental
illness, rearing rodents in persistent postweaning social isolation has been established as a …

Early-life adversity increases the vulnerability to develop psychopathologies and cognitive
decline later in life. This association is supported by clinical and preclinical studies …

The protracted development of structural and functional brain connectivity within distributed
association networks coincides with improvements in higher-order cognitive processes such …

Introduction Environmental perturbations during critical periods can have pervasive,
organizational effects on neurodevelopment. To date, the literature examining the long-term …

Childhood learning difficulties and developmental disorders are common, but progress
toward understanding their underlying brain mechanisms has been slow. Structural …

Structural covariance examines covariation of gray matter morphology between brain
regions and across individuals. Despite significant interest in the influence of age on …

Childhood adversity is one of the strongest predictors of adolescent mental illness.
Therefore, it is critical that the mechanisms that aid resilient functioning in individuals …

The brain's neural circuitry plays a ubiquitous role across domains in cognitive processing
and undergoes extensive reorganization during the course of development in part as a …

The overarching objective is to review how early exposure to adversity interacts with
inflammation to alter brain maturation. Both adversity and inflammation are significant risk …