NATb/NAT1*4 promotes greater arylamine N‐acetyltransferase 1 mediated DNA adducts and mutations than NATa/NAT1*4 following exposure to 4‐aminobiphenyl
LM Millner, MA Doll, J Cai, JC States… - Molecular …, 2012 - Wiley Online Library
Abstract N‐acetyltransferase 1 (NAT1) is a phase II metabolic enzyme responsible for the
biotransformation of aromatic and heterocyclic amine carcinogens such as 4‐aminobiphenyl …
biotransformation of aromatic and heterocyclic amine carcinogens such as 4‐aminobiphenyl …
Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases
DW Hein, MA Doll, TD Rustan, K Gray, Y Feng… - …, 1993 - academic.oup.com
A genetic polymorphism at the NAT2 gene locus, encoding for polymorphic N-
acetyltransferase (NAT2), segregates individuals into rapid, intermediate or slow acetylator …
acetyltransferase (NAT2), segregates individuals into rapid, intermediate or slow acetylator …
Effects of single nucleotide polymorphisms in human N‐acetyltransferase 2 on metabolic activation (O‐acetylation) of heterocyclic amine carcinogens
DW Hein, AJ Fretland, MA Doll - International journal of cancer, 2006 - Wiley Online Library
Abstract N‐Acetyltransferase 2 (NAT2) catalyzes the O‐acetylation of N‐hydroxy
heterocyclic amines such as N‐hydroxy‐2‐amino‐3, 8‐dimethylimidazo [4, 5‐f] quinoxaline …
heterocyclic amines such as N‐hydroxy‐2‐amino‐3, 8‐dimethylimidazo [4, 5‐f] quinoxaline …
Acetylation of putative arylamine and alkylaniline carcinogens in immortalized human fibroblasts transfected with rapid and slow acetylator N-acetyltransferase 2 …
Exposure to alkylanilines found in tobacco smoke and indoor air is associated with risk of
bladder cancer. Genetic factors significantly influence the metabolism of arylamine …
bladder cancer. Genetic factors significantly influence the metabolism of arylamine …
Influence of arylamine n‐acetyltransferase, sex, and age on 4‐aminobiphenyl‐induced in vivo mutant frequencies and spectra in mouse liver
S Wang, KS Sugamori, D Brenneman… - Environmental and …, 2012 - Wiley Online Library
One model for cancer initiation by 4‐aminobiphenyl (ABP) involves N‐oxidation by
cytochrome P450 CYP1A2 followed by O‐conjugation by N‐acetyltransferase (s) NAT1 …
cytochrome P450 CYP1A2 followed by O‐conjugation by N‐acetyltransferase (s) NAT1 …
Rabbit N-acetyltransferase 2 genotyping method to investigate role of acetylation polymorphism on N- and O-acetylation of aromatic and heterocyclic amine …
DW Hein, MA Doll - Archives of toxicology, 2017 - Springer
The rabbit was the initial animal model to investigate the acetylation polymorphism
expressed in humans. Use of the rabbit model is compromised by lack of a rapid non …
expressed in humans. Use of the rabbit model is compromised by lack of a rapid non …
Effect of N-acetyltransferase 2 genetic polymorphism on 4,4′-methylenebis(2-chloroaniline)-induced genotoxicity and oxidative stress
MR Habil, RA Salazar-González, MA Doll… - Archives of …, 2023 - Springer
Methylenebis (2-chloroaniline) or MOCA is an aromatic amine used primarily in
polyurethane and rubber industry. MOCA has been linked to hepatomas in animal studies …
polyurethane and rubber industry. MOCA has been linked to hepatomas in animal studies …
2‐amino‐1‐methyl‐6‐phenylimidazo [4, 5‐b] pyridine‐induced DNA adducts and genotoxicity in chinese hamster ovary (CHO) cells expressing human CYP1A2 and …
KJ Metry, S Zhao, JR Neale, MA Doll… - … in cooperation with …, 2007 - Wiley Online Library
Heterocyclic amine carcinogens such as 2‐amino‐1‐methyl‐6‐phenylimidazo [4, 5‐b]
pyridine (PhIP) are present in diet and cigarette smoke. Bioactivation in humans includes N …
pyridine (PhIP) are present in diet and cigarette smoke. Bioactivation in humans includes N …
The effects of genetic variation in N-acetyltransferases on 4-aminobiphenyl genotoxicity in mouse liver
CA McQueen, B Chau, RP Erickson… - Chemico-biological …, 2003 - Elsevier
Inbred, congenic and transgenic strains of mice were characterized for acetylation of p-
aminobenzoic (PABA) and the carcinogen 4-aminobiphenyl (4ABP). C57Bl/6 mice have the …
aminobenzoic (PABA) and the carcinogen 4-aminobiphenyl (4ABP). C57Bl/6 mice have the …
Recombinant expression and catalytic analysis of rapid and slow acetylator Syrian hamster chimeric NAT2 alleles
DW Hein, RJ Ferguson, MA Doll, AC Deitz - Archives of toxicology, 1997 - Springer
Polymorphic aromatic amine N-acetyltransferase (NAT2) catalyzes the N-acetylation of
aromatic amines and the metabolic activation of N-hydroxyarylamines (via O-acetylation) …
aromatic amines and the metabolic activation of N-hydroxyarylamines (via O-acetylation) …