Aminobiphenyl (4-ABP) is a human and mouse bladder carcinogen. Epidemiological studies
have shown that individuals with a slow acetylator phenotype, especially those exposed to …

Aromatic and heterocyclic amine carcinogens present in the diet and in cigarette smoke
induce breast tumors in rats. N-acetyltransferase 1 (NAT1) and N-acetyltransferase 2 (NAT2) …

We earlier developed the Chinese hamster ovary UV5P3 cell line that expresses
cytochrome P4501A2 and lacks nucleotide excision repair for studying metabolism and …

N-Acetyltransferases (NAT) are key enzymes in the conjugation of certain drugs and other
xenobiotics with an arylamine structure. Polymorphisms in NAT2 have long been recognized …

Rat lines congenic for the rat N-acetyltransferase 2 [(RAT) Nat2] gene were constructed and
characterized. F344 (homozygous Nat2 rapid) males were mated to Wistar Kyoto …

Arylamine N-acetyltransferases (Nat) 1 and 2 catalyze the N-acetylation of aromatic amine
and hydrazine drugs and carcinogens. After N-hydroxylation, they also catalyze the …

The use of new psychoactive substances (NPS) as drugs of abuse is common and
increasingly popular, particularly among youth and neglected communities. Recent studies …

Human monomorphic and polymorphic arylamine acetyltransferases (EC 2.3. 1.5) were
expressed in monkey kidney COS-1 cells and used to study the N-and O-acetylation of a …

2-Amino-9 H-pyrido [2, 3-b] indole (AαC) is a carcinogenic heterocyclic aromatic amine
(HAA) that is produced in high quantities in tobacco smoke and that also forms in charred …

Aromatic and heterocyclic amines require metabolic activation to electrophilic intermediates
that initiate carcinogenesis. N-Acetyltransferase 1 (NAT1) and 2 (NAT2) are important …