Functional characterization of the Aspergillus fumigatus calcineurin

ME da Silva Ferreira, T Heinekamp, A Härtl… - Fungal Genetics and …, 2007 - Elsevier
Aspergillus fumigatus is an aggressive opportunistic pathogen of humans as well as a major
allergen. Environmental sensing and retrieving essential nutrients from the environment are …

Calcineurin Controls Growth, Morphology, and Pathogenicity in Aspergillus fumigatus

WJ Steinbach, RA Cramer Jr, BZ Perfect… - Eukaryotic …, 2006 - Am Soc Microbiol
Calcineurin is implicated in a myriad of human diseases as well as homeostasis and
virulence in several major human pathogenic microorganisms. The fungus Aspergillus …

Aspergillus fumigatus Calcipressin CbpA Is Involved in Hyphal Growth and Calcium Homeostasis

N Pinchai, BZ Perfect, PR Juvvadi, JR Fortwendel… - Eukaryotic …, 2009 - Am Soc Microbiol
Calcineurin is a conserved protein phosphatase that plays a critical role in Ca2+ signaling
and stress responses. Previously, a new class of conserved calcineurin-binding proteins, the …

Functional Characterization of an Aspergillus fumigatus Calcium Transporter (PmcA) that Is Essential for Fungal Infection

TM Dinamarco, FZ Freitas, RS Almeida, NA Brown… - PLoS …, 2012 - journals.plos.org
Aspergillus fumigatus is a primary and opportunistic pathogen, as well as a major allergen,
of mammals. The Ca+ 2-calcineurin pathway affects virulence, morphogenesis and …

Calcineurin-Mediated Regulation of Hyphal Growth, Septation, and Virulence in Aspergillus fumigatus

PR Juvvadi, F Lamoth, WJ Steinbach - Mycopathologia, 2014 - Springer
Calcineurin is a heterodimeric protein phosphatase complex composed of catalytic (CnaA)
and regulatory (CnaB) subunits and plays diverse roles in regulating fungal stress …

Phosphorylation of Calcineurin at a Novel Serine-Proline Rich Region Orchestrates Hyphal Growth and Virulence in Aspergillus fumigatus

PR Juvvadi, C Gehrke, JR Fortwendel, F Lamoth… - PLoS …, 2013 - journals.plos.org
The fungus Aspergillus fumigatus is a leading infectious killer in immunocompromised
patients. Calcineurin, a calmodulin (CaM)-dependent protein phosphatase comprised of …

Functional characterization of the Aspergillus fumigatus CRZ1 homologue, CrzA

FM Soriani, I Malavazi… - Molecular …, 2008 - Wiley Online Library
The protein phosphatase calcineurin is an important mediator connecting calcium‐
dependent signalling to various cellular responses in multiple organisms. In fungi …

Identification of possible targets of the Aspergillus fumigatus CRZ1 homologue, CrzA

FM Soriani, I Malavazi, M Savoldi, E Espeso… - BMC microbiology, 2010 - Springer
Background Calcineurin, a serine/threonine-specific protein phosphatase, plays an
important role in the control of cell morphology and virulence in fungi. Calcineurin regulates …

Coping with stress: calmodulin and calcineurin in model and pathogenic fungi

PR Kraus, J Heitman - Biochemical and biophysical research …, 2003 - Elsevier
Calcium signaling via calmodulin and calcineurin is critical for the regulation of stress
responses in fungi. The functions of calmodulin and calcineurin are largely conserved …

Calcineurin Target CrzA Regulates Conidial Germination, Hyphal Growth, and Pathogenesis of Aspergillus fumigatus

RA Cramer Jr, BZ Perfect, N Pinchai, S Park… - Eukaryotic …, 2008 - Am Soc Microbiol
The calcineurin pathway is a critical signal transduction pathway in fungi that mediates
growth, morphology, stress responses, and pathogenicity. The importance of the calcineurin …