Genetic variants and multiple myeloma risk: IMMEnSE validation of the best reported associations—an extensive replication of the associations from the candidate …

A Martino, D Campa, A Jurczyszyn… - … , biomarkers & prevention, 2014 - AACR
Background: Genetic background plays a role in multiple myeloma susceptibility. Several
single-nucleotide polymorphisms (SNP) associated with genetic susceptibility to multiple …

Genetic polymorphisms and multiple myeloma risk: a meta-analysis

P Zhang, B Liu - Annals of Hematology, 2020 - Springer
Previous researches exploring associations between multiple myeloma (MM) and genetic
polymorphisms showed controversial results. In this investigation, we aimed to make a meta …

[HTML][HTML] A polygenic risk score for multiple myeloma risk prediction

F Canzian, C Piredda, A Macauda… - European Journal of …, 2022 - nature.com
There is overwhelming epidemiologic evidence that the risk of multiple myeloma (MM) has a
solid genetic background. Genome-wide association studies (GWAS) have identified 23 risk …

Does a multiple myeloma polygenic risk score predict overall survival of patients with myeloma?

A Macauda, A Clay-Gilmour, T Hielscher… - … Biomarkers & Prevention, 2022 - AACR
Background: Genome-wide association studies (GWAS) of multiple myeloma in populations
of European ancestry (EA) identified and confirmed 24 susceptibility loci. For other cancers …

A meta-analysis of multiple myeloma risk regions in African and European ancestry populations identifies putatively functional loci

KA Rand, C Song, E Dean, DJ Serie, K Curtin… - … , biomarkers & prevention, 2016 - AACR
Background: Genome-wide association studies (GWAS) in European populations have
identified genetic risk variants associated with multiple myeloma. Methods: We performed …

[HTML][HTML] Genome-wide association study identifies multiple susceptibility loci for multiple myeloma

JS Mitchell, N Li, N Weinhold, A Försti, M Ali… - Nature …, 2016 - nature.com
Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis.
Genome-wide association studies have transformed our understanding of MM …

Search for multiple myeloma risk factors using Mendelian randomization

M Went, AJ Cornish, PJ Law, B Kinnersley… - Blood …, 2020 - ashpublications.org
The etiology of multiple myeloma (MM) is poorly understood. Summary data from genome-
wide association studies (GWASs) of multiple phenotypes can be exploited in a Mendelian …

MyelomA genetics international consortium

G Morgan, HE Johnsen, H Goldschmidt… - Leukemia & …, 2012 - Taylor & Francis
While the etiology of multiple myeloma (MM) is largely unknown, evidence for an inherited
genetic susceptibility is provided by the two-fold increased risk of the disease seen in first …

Genetics and molecular epidemiology of multiple myeloma: the rationale for the IMMEnSE consortium

A Martino, J Sainz, G Buda… - International …, 2012 - spandidos-publications.com
There is strong evidence suggesting the presence of a genetic component in the aetiology of
multiple myeloma (MM). However no genetic risk factors have been unequivocally …

[PDF][PDF] Impact of polymorphic variation at 7p15. 3, 3p22. 1 and 2p23. 3 loci on risk of multiple myeloma.

A Martino, D Campa, K Jamroziak… - British journal of …, 2012 - researchgate.net
Multiple myeloma (MM) is the second most common haematological cancer after non-
Hodgkin lymphoma (Raab et al, 2009), with a worldwide age-standardized rate of 1Á5/100 …