Spermatogonial development is a key process during spermatogenesis to prepare germ
cells to enter meiosis. While the initial point of spermatogonial differentiation is well …

To clarify the functions and mechanism of stimulated by retinoic acid gene 8 (Stra8) in
spermatogenesis, we analyzed the testes from Stra8 knockout and wild-type mice during the …

Retinoic acid (RA) induces spermatogonial differentiation, but the mechanism by which it
operates remains largely unknown. We developed a germ cell culture assay system to study …

We analysed the phenotypic outcome of a Stra8-null mutation on male meiosis. Because the
mutant spermatocytes (1) underwent premeiotic DNA replication,(2) displayed cytological …

In mice, the entry of germ cells into meiosis crucially depends on the expression of
stimulated by retinoic acid gene 8 (Stra8). Stra8 is expressed specifically in pre-meiotic germ …

Abstract STRA8 (Stimulated By Retinoic Acid Gene 8) is a retinoic acid (RA) induced gene
that plays vital roles in spermatogonial proliferation, differentiation and meiosis. The SETD8 …

Mammalian spermatogenesis—the transformation of stem cells into millions of haploid
spermatozoa—is elaborately organized in time and space. We explored the underlying …

In eukaryotes, diploid cells give rise to haploid cells via meiosis, a program of two cell
divisions preceded by one round of DNA replication. Although key molecular components of …

Entering meiosis strictly depends on stimulated by retinoic acid 8 (Stra8) gene function in
mammals. This gene is missing in a number of fish species, including medaka and …

The transition from mitotic to meiotic cell cycles is essential for haploid gamete formation and
fertility. Stimulated by retinoic acid gene 8 (Stra8) is an essential gatekeeper of meiotic …