The more the merrier: effects of macromolecular crowding on the structure and dynamics of biological membranes

M Löwe, M Kalacheva, AJ Boersma… - The FEBS …, 2020 - Wiley Online Library
Proteins are essential and abundant components of cellular membranes. Being densely
packed within the limited surface area, proteins fulfil essential tasks for life, which include …

[HTML][HTML] Effects of protein crowding on membrane systems

G Guigas, M Weiss - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2016 - Elsevier
Cellular membranes are typically decorated with a plethora of embedded and adsorbed
macromolecules, eg proteins, that participate in numerous vital processes. With typical …

Strength in numbers: effect of protein crowding on the shape of cell membranes

VT Ruhoff, G Moreno-Pescador… - Biochemical Society …, 2022 - portlandpress.com
Continuous reshaping of the plasma membrane into pleomorphic shapes is critical for a
plethora of cellular functions. How the cell carries out this enigmatic control of membrane …

Crowding effects of membrane proteins

HX Zhou - The journal of physical chemistry B, 2009 - ACS Publications
In cell membranes, membrane proteins occupy∼ 30% of the total surface area. Crowding
effects similar to those in the solution phase are thus to be expected. In addition, there are …

The impact of physiological crowding on the diffusivity of membrane bound proteins

JR Houser, DJ Busch, DR Bell, B Li, P Ren… - Soft Matter, 2016 - pubs.rsc.org
Diffusion of transmembrane and peripheral membrane-bound proteins within the crowded
cellular membrane environment is essential to diverse biological processes including …

Clustering on membranes: fluctuations and more

L Johannes, W Pezeshkian, JH Ipsen, JC Shillcock - Trends in cell biology, 2018 - cell.com
Clustering of extracellular ligands and proteins on the plasma membrane is required to
perform specific cellular functions, such as signaling and endocytosis. Attractive forces that …

Engineered molecular sensors for quantifying cell surface crowding

SC Takatori, S Son, DSW Lee… - Proceedings of the …, 2023 - National Acad Sciences
Cells mediate interactions with the extracellular environment through a crowded assembly of
transmembrane proteins, glycoproteins and glycolipids on their plasma membrane. The …

Macromolecular crowding at membrane interfaces: adsorption and alignment of membrane peptides

C Aisenbrey, B Bechinger, G Gröbner - Journal of molecular biology, 2008 - Elsevier
Association of proteins to cellular membranes is involved in various biological processes.
Various theoretical models have been developed to describe this adsorption mechanism …

The differential response of proteins to macromolecular crowding

M Candotti, M Orozco - PLoS computational biology, 2016 - journals.plos.org
The habitat in which proteins exert their function contains up to 400 g/L of macromolecules,
most of which are proteins. The repercussions of this dense environment on protein …

[HTML][HTML] Membrane bending by protein crowding is affected by protein lateral confinement

J Derganc, A Čopič - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2016 - Elsevier
Crowding of asymmetrically-distributed membrane proteins has been recently recognized as
an important factor in remodeling of biological membranes, for example during transport …