This review discusses recent work that has focused on the interaction of leptin with various
neuroendocrine pathways in the brain and in the periphery to affect food intake. Additional …

Leptin is a metabolic hormone secreted from adipose tissue, also called satiety hormone.
This hormone plays an important role in the regulation of body weight and energy …

Leptin, a protein containing 167 amino acids, demonstrates structural similarities with
cytokine family and is mainly produced by adipocytes. The leptin receptor (OB-R) is a large …

Obesity results from an abnormal accumulation of fat in the white adipose tissue. Recent
research utilizing genetic models of obesity in rodents has implicated a major role of leptin …

Historically, adipose tissue was considered to be a passive storage vessel discharging
nutrients in times of famine and accumulating fat in times of surfeit. This view changed with …

An imbalance between calorie intake and energy expenditure produces obesity. It has been
a major problem in societies of the developing and developed world. In obesity an excessive …

Leptin, a peptide hormone (167 aa) mainly expressed in adipocytes, and its hypothalamic
receptors are integral components of a complex physiological system evolved to regulate …

Leptin, discovered through positional cloning 15 years ago, is an adipocyte-secreted
hormone with pleiotropic effects in the physiology and pathophysiology of energy …

This review focused on leptin controlled pathways in the brain, although there are many
players involved, within and outside the brain. Topics include: leptin; signalling molecules …

Leptin: in search of role(s) in human physiology and pathophysiology Page 1 Clinical
Endocrinology (1998) 49, 551–567 Leptin: in search of role(s) in human physiology and …