The adipocyte-derived hormone, leptin, regulates food intake and systemic fuel metabolism;
ob/ob mice, which lack functional leptin, exhibit an obesity syndrome that is similar to morbid …

Leptin, a 167 aminoacid protein product of the ob gene, is an adipocyte-derived hormone
that acts as a major regulator for food intake and energy homeostasis. Leptin is expressed …

Obesity is the result of a positive balance between total energy intake and its catabolism.
Although many factors are involved in the regulation of energy metabolism, the discovery of …

Leptin is an adipocyte-derived signal factor (167 amino acid protein) encoded by the ob
gene in chromosome 7q31 that regulates eating behaviour via central neuroendocrine …

The world obesity problem is now reaching pandemic proportions. Using criteria drawn up
by the World Health Organisation (WHO) defining 'overweight'as a BMI of over 25 and …

Since its discovery over fifteen years ago, Leptin remains the cornerstone for researchers
because of its important role in central control of energy metabolism. Apart from role in …

Leptin is a hormone derived from adipose tissue and the small intestine, mainly in
enterocytes; it helps regulate the energy balance by suppressing hunger, resulting in …

Unravelling the diverse hormonal and neuroendocrine systems which regulate energy
balance and body fat has been a long-standing challenge in biology, with obesity as an …

Leptin was the first described of a growing number of hormones produced by adipose tissue
(Rajala and Scherer, 2003; Havel, 2004). Leptin is integrally involved in the regulation of …

Body weight and body composition in humans are determined by the complex interaction of
genetic, environmental, behavioral, and social factors. The central nervous system, primarily …