Leptin burst onto the scene in 1994 and transformed research into obesity and energy
balance. Immediately, hopes were raised that this peptide, secreted by adipose tissue, might …

A decade ago, leptin (from the greek lepto meaning 'thin') was identified as the product of the
ob gene. 1 This adipocyte‐derived hormone was found to suppress feeding and stimulate …

The regulation of body fat stores and blood glucose levels is critical for survival. This review
highlights growing evidence that leptin action in the central nervous system plays a key role …

It is widely believed that the primary physiologic role of leptin is to prevent obesity by
regulating food intake and thermogenesis through actions on hypothalamic centers. Here …

The biology of leptin has been studied most extensively in the central nervous system for the
regulation of food intake and energy balance. In recent years, a growing number of …

Leptin has emerged over the past decade as a key hormone in not only the regulation of
food intake and energy expenditure but also in the regulation of neuroendocrine and …

The cloning of the ob gene in 1994 and reports in 1995 that administration of the encoded
protein leptin reversed obesity of ob/ob mice that lacked it were major breakthroughs in …

The leptin hormone not only examines its effects on energy balance and weight control but
also delves into its profound impacts on brain functions and the immune system. The …

Much attention has focused on the effects of leptin as a central satiety agent. There is now a
significant amount of evidence that leptin is active in the periphery. This review focuses on …

Leptin, a peptide hormone secreted by adipocytes, plays a central role in controlling appetite
and weight in both rodents and humans. Basic science and clinical research suggest that …