Adipose tissue performs complex metabolic and endocrine functions. Among the endocrine
products produced by adipose tissue are tumour necrosis factor α, interleukin 6, acylation …

Leptin is a hormone produced by the adipose tissue, which has effects on the central
nervous system. Leptin is bound to its Ob receptor on hypothalamic neurons to inhibit …

Body-weight regulation has for a long time been considered to be mainly a question of 'to
eat or not to eat', subject to free will. However, a simple calculation sheds doubt on this view; …

The importance of the central nervous system in the regulation of energy homeostasis was
derived from the clinical observation of excessive subcutaneous fat in patients with pituitary …

Obesity is characterized by an abnormal increase in adipose tissue mass and is regarded as
a neurobehavioral as well as a metabolic disorder. Increases in body fat are caused by even …

The discovery of the ob gene and leptin heralded a new beginning in our understanding of
neuroendocrine mechanisms regulating food intake and body composition. However, in …

Obesity is a multi-causal disease that includes exogenous and endogenous factors. We
highlight leptin, a synthesized hormone in the adipose tissue, whose receptor is in the …

Leptin is a master regulator of energy balance and body adiposity. Additionally, leptin exerts
important control on glucose homeostasis, thermogenesis, autonomic nervous system and …

The discovery of leptin has significantly advanced our understanding of the metabolic
importance of adipose tissue and has revealed that both leptin deficiency and leptin excess …

Obesity, defined as an increase in body fat, is a growing problem in Western societies. In
Canada over 30% of the population is obese. Obesity is associated with increases in …