The discovery of leptin, the obese (ob) gene product which is not expressed as a functional
protein in ob/ob mice, focused the scientific community's attention on its role as an anorexic …

Leptin is secreted by white adipocytes and circulates in the blood stream bound to leptin-
specific receptors. Leptin receptors also function to transport leptin through the blood–brain …

The description of the adipose tissue hormone leptin has led to important discoveries. Leptin
plays a role not only in the regulation of metabolic efficiency, energy expenditure, food …

The recently discovered leptin is thought to be a satiety signal regulating food intake. In
mice, it has been shown that on a high-fat diet leptin concentration increases, but the …

Leptin is a circulating hormone that is secreted in proportion to fat mass. It can reduce
bodyweight by activating signalling molecules in the brain. Leptin appears to affect …

Many studies have reported the difficulty most subjects have in maintaining weight loss.
Leptin is a cytokine-like protein made in adipose tissue and is transported into the brain by …

Recent proof-of-concept studies involving leptin administration to humans with leptin
deficiency support its critical role in regulating energy homeostasis, neuroendocrine and …

The discovery of the adipostatic hormone leptin has transformed our understanding of the
neurobiology of appetite control and has helped to establish the biological basis of obesity …