We demonstrate label-free three-photon imaging of intact organoids (~ 2 mm depth) derived
from Rett syndrome patients. Long-term imaging of live organoids shows that mutant …

Human cerebral organoids are unique in their development of progenitor-rich zones akin to
ventricular zones from which neuronal progenitors differentiate and migrate radially …

Rett Syndrome (RTT) is a pervasive, X-linked neurodevelopmental disorder that
predominantly affects girls. It is mostly caused by a sporadic mutation in the gene encoding …

Cerebral organoids, self-organizing structures with increased cellular diversity and
longevity, have addressed shortcomings in mimicking human brain complexity and …

The theme of this dissertation project has been to look at the basic mechanisms of cerebral
cortical development using the latest technological advances in time-lapse multiphoton …

Abstract Development of the mammalian brain proceeds in a precisely controlled sequence
of cell divisions, migration, differentiation, and synaptogenesis. It is a process of precise …

Optical imaging of the native brain | Nature Methods Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

Highlights•We describe recent advances in optical imaging of neurodevelopment.•Advances
in multiphoton microscopy provide increased imaging depth and speed for investigation of …

In the primary visual cortex of non-rodent mammals, neurons are clustered according to their
preference for stimulus features such as orientation 1-4, direction 5-7, ocular dominance 8, 9 …

abstract We describe a simple and low-cost system for intrinsic optical signal (IOS) imaging
using stable LED light sources, basic microscopes, and commonly available CCD cameras …