Porphyromonas gingivalis induction of TLR2 association with Vinculin enables PI3K activation and immune evasion

K Pandi, S Angabo, J Gnanasekaran, H Makkawi… - PLoS …, 2023 - journals.plos.org
Porphyromonas gingivalis is a Gram-negative anaerobic bacterium that thrives in the
inflamed environment of the gingival crevice, and is strongly associated with periodontal …

P. gingivalis–Induced TLR2 Interactome Analysis Reveals Association with PARP9

K Pandi, S Angabo, H Makkawi… - Journal of Dental …, 2024 - journals.sagepub.com
Porphyromonas gingivalis is a Gram-negative anaerobic bacterium strongly associated with
periodontal disease. Toll-like receptor 2 (TLR2) is indispensable for the host response to P …

Porphyromonas gingivalis Stimulates TLR2-PI3K Signaling to Escape Immune Clearance and Induce Bone Resorption Independently of MyD88

H Makkawi, S Hoch, E Burns, K Hosur… - Frontiers in cellular …, 2017 - frontiersin.org
Porphyromonas gingivalis is a gram-negative anaerobic periodontal pathogen that persists
in dysbiotic mixed-species biofilms alongside a dense inflammatory infiltrate of neutrophils …

Accessory fimbrial subunits and PPAD are necessary for TLR2 activation by Porphyromonas gingivalis

A Wielento, GP Bereta, K Szczęśniak… - Molecular oral …, 2023 - Wiley Online Library
Porphyromonas gingivalis is an oral pathogen that promotes dysbiosis by quenching the
bactericidal activity of the host immune system while maintaining chronic inflammation …

Porphyromonas gingivalis manipulates complement and TLR signaling to uncouple bacterial clearance from inflammation and promote dysbiosis

T Maekawa, JL Krauss, T Abe, R Jotwani… - Cell host & …, 2014 - cell.com
Certain low-abundance bacterial species, such as the periodontitis-associated oral
bacterium Porphyromonas gingivalis, can subvert host immunity to remodel a normally …

Cutting Edge: TLR2 is required for the innate response to Porphyromonas gingivalis: activation leads to bacterial persistence and TLR2 deficiency attenuates induced …

E Burns, G Bachrach, L Shapira… - The Journal of …, 2006 - journals.aai.org
Periodontitis is a chronic inflammatory disease that leads to destruction of the attachment
apparatus of the teeth. The presence of particular oral bacteria and the host inflammatory …

Induction of distinct TLR2-mediated proinflammatory and proadhesive signaling pathways in response to Porphyromonas gingivalis fimbriae

G Hajishengallis, M Wang, S Liang - The journal of immunology, 2009 - journals.aai.org
The oral pathogen Porphyromonas gingivalis, as well as its purified fimbriae, are known to
activate TLR2 and induce proinflammatory and proadhesive effects. The TLR2 …

Gingipains Inactivate a Cell Surface Ligand on Porphyromonas gingivalis That Induces TLR2‐ and TLR4‐Independent Signaling

M Kishimoto, A Yoshimura, M Naito… - Microbiology and …, 2006 - Wiley Online Library
Arginine‐specific gingipain and lysine‐specific gingipain are two major cysteine proteinases
produced by Porphyromonas gingivalis. To clarify the role of gingipains in the interaction …

TLR2 Activation by Porphyromonas gingivalis Requires Both PPAD Activity and Fimbriae

A Wielento, GP Bereta, KB Łagosz-Ćwik… - Frontiers in …, 2022 - frontiersin.org
Porphyromonas gingivalis, a keystone oral pathogen implicated in development and
progression of periodontitis, may also contribute to the pathogenicity of diseases such as …

TLR2-dependent inflammatory response to Porphyromonas gingivalis is MyD88 independent, whereas MyD88 is required to clear infection

E Burns, T Eliyahu, S Uematsu, S Akira… - The journal of …, 2010 - journals.aai.org
Porphyromonas gingivalis is a Gram-negative anaerobe considered to be a major
periodontal pathogen. TLR2 plays a central role in the response to P. gingivalis infection in …