Gap junctional intercellular communication mediates the transfer of small molecules from the
cytoplasm of one cell to that of neighbouring cells. Connexins are the proteins that form the …

Gap junctional intercellular communication plays a key role in the maintenance of
homeostasis in multicellular organisms. Reflecting deranged homeostasis in cancer cells …

Although the specific role of connexin-mediated gap junctional intercellular communication
in the control of cell homeostasis, proliferation, and death are still not clear, several lines of …

Evidence is accumulating that connexin (Cx) genes form a family of tumor-suppressor
genes. Our long-standing study revealed that, in almost all tumors, some abnormality in gap …

Results from short-term tests for carcinogens and our advanced knowledge on cellular and
molecular mechanisms of carcinogenesis strongly suggest that carcinogens do not induce …

The loss of homeostasis which characterizes tumor growth is probably the result of a
deregulated intercellular communication capacity of the cancer cells. The deregulation of …

Gap junctions are membrane structures made of intercellular channels which permit the
diffusion from cytoplasm to cytoplasm of small hydrophilic molecules. Nearly 40 years ago …

Gap junctions, intercellular channels structured by the connexin protein family, have been
implicated in the control of cell homeostasis, proliferation, differentiation and death. A loss of …

Gap junctions are cellular structures which permit direct exchanges of small molecules from
cytoplasm to cytoplasm in most of the cells of metazoan organisms. For four decades, it has …

Gap junctions are comprised of proteinaceous, plasma membrane channels that link the
interiors of adjacent cells and permit cells to directly exchange small (< 1,000 Daltons) …