Transforming growth factor-β (TGFβ) isoforms are upregulated and activated in myocardial
diseases and have an important role in cardiac repair and remodelling, regulating the …

Myocardial TGF-β expression is upregulated in experimental models of myocardial infarction
and cardiac hypertrophy, and in patients with dilated or hypertrophic cardiomyopathy …

The adult mammalian heart has negligible regenerative capacity. Following myocardial
infarction, sudden necrosis of cardiomyocytes triggers an intense inflammatory reaction that …

Myocardial infarction (MI) is a major form of heart disease that leads to immediate
cardiomyocyte death due to ischemia and eventually fibrosis and scar formation and further …

Abstract Transforming Growth Factor (TGF)-β is markedly induced and rapidly activated in
the infarcted myocardium. However, understanding of the exact role of TGF-β signaling in …

The importance of fibrosis in organ pathology and dysfunction appears to be increasingly
relevant to a variety of distinct diseases. In particular, a number of different cardiac …

Transforming growth factor-β (TGF-β) is a common mediator of cancer progression and
fibrosis. Fibrosis can be a significant pathology in multiple organs, including the heart. In this …

The members of the transforming growth factor β (TGF-β) superfamily are essential
regulators of cell differentiation, phenotype and function, and have been implicated in the …

The cytokine transforming growth factor β (TGFβ) is a major contributor to fibrogenic
responses both in vitro and in vivo. TGFβ possesses many functions; thus, broadly targeting …

Transforming growth factor (TGF-β) is a multifunctional peptide growth factor that has an
important role in the regulation of cell growth, differentiation, and repair in a variety of …