Insights into the molecular pathogenesis of progression in multiple sclerosis: potential implications for future therapies

J Imitola, T Chitnis, SJ Khoury - Archives of neurology, 2006 - jamanetwork.com
Despite recent advances in the diagnosis and treatment of multiple sclerosis, we still lack a
consensus regarding the causes, pathogenesis, and mechanisms of disease progression …

Multiple sclerosis: genetics, biomarkers, treatments

PP Axisa, DA Hafler - Current opinion in neurology, 2016 - journals.lww.com
Breakthroughs in the field of multiple sclerosis have led to a better understanding of the
physiopathology of the disease, follow up, and treatment of the patients that develop …

The spectrum of multiple sclerosis: new lessons from pathology

W Brück, C Stadelmann - Current opinion in neurology, 2005 - journals.lww.com
The spectrum of multiple sclerosis: new lessons from patholo... : Current Opinion in
Neurology The spectrum of multiple sclerosis: new lessons from pathology : Current …

[HTML][HTML] The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration

SL Hauser, JR Oksenberg - Neuron, 2006 - cell.com
The autoimmune model of multiple sclerosis (MS) pathogenesis provided for many years a
useful but incomplete conceptual framework for understanding the complex array of factors …

Mechanisms underlying progression in multiple sclerosis

M Absinta, H Lassmann, BD Trapp - Current opinion in neurology, 2020 - journals.lww.com
The neuropathological and biological understanding of disease progression in multiple
sclerosis have progressed in the last few years. As a consequence, new therapeutic …

Pathogenesis of multiple sclerosis

JW Rose, NG Carlson - CONTINUUM: Lifelong Learning in …, 2007 - journals.lww.com
Significant progress toward understanding the pathogenesis of multiple sclerosis (MS) has
been achieved in recent years. Scientific and technologic advances are providing a …

Characterizing the mechanisms of progression in multiple sclerosis: evidence and new hypotheses for future directions

EM Frohman, M Filippi, O Stuve, SG Waxman… - Archives of …, 2005 - jamanetwork.com
Major advancements have been achieved in our ability to diagnose multiple sclerosis (MS)
and to commence treatment intervention with agents that can favorably affect the disease …

[HTML][HTML] Diverse targets for intervention during inflammatory and neurodegenerative phases of multiple sclerosis

SS Zamvil, L Steinman - Neuron, 2003 - cell.com
Multiple sclerosis (MS) is an autoimmune central nervous system (CNS) demyelinating
disease that causes relapsing and chronic neurologic impairment. Recent observations …

Knowns and unknowns in the future of multiple sclerosis treatment

O Stüve - Journal of the neurological sciences, 2009 - Elsevier
Multiple sclerosis is a chronic disease confined to the central nervous system. Its
pathological hallmarks are neuroinflammation, de-and re-myelination, neurodegeneration …

Multiple sclerosis: lessons from neuropathology

CF Lucchinetti, W Brueck, M Rodriguez… - Seminars in …, 1998 - thieme-connect.com
The focus of multiple sclerosis (MS) research has been on attempts to identify the specific
pathogenic mechanism responsible for producing the multifocal central nervous system …