[HTML][HTML] Allele-specific expression and high-throughput reporter assay reveal functional genetic variants associated with alcohol use disorders
X Rao, KS Thapa, AB Chen, H Lin, H Gao… - Molecular …, 2021 - nature.com
Genome-wide association studies (GWAS) of complex traits, such as alcohol use disorders
(AUD), usually identify variants in non-coding regions and cannot by themselves distinguish …
(AUD), usually identify variants in non-coding regions and cannot by themselves distinguish …
Identification of functional genetic variants associated with alcohol dependence and related phenotypes using a high‐throughput assay
KS Thapa, AB Chen, D Lai, X Xuei… - Alcoholism: Clinical …, 2020 - Wiley Online Library
Background Genome‐wide association studies (GWAS) of alcohol dependence (AD) and
related phenotypes have identified multiple loci, but the functional variants underlying the …
related phenotypes have identified multiple loci, but the functional variants underlying the …
Genetic underpinnings of the transition from alcohol consumption to alcohol use disorder: shared and unique genetic architectures in a cross-ancestry sample
Objective: Recent genome-wide association studies (GWASs) of alcohol-related phenotypes
have uncovered key differences in the underlying genetic architectures of alcohol …
have uncovered key differences in the underlying genetic architectures of alcohol …
Beyond genome‐wide significance: integrative approaches to the interpretation and extension of GWAS findings for alcohol use disorder
JE Salvatore, S Han, SP Farris, KM Mignogna… - Addiction …, 2019 - Wiley Online Library
Alcohol use disorder (AUD) is a heritable complex behavior. Due to the highly polygenic
nature of AUD, identifying genetic variants that comprise this heritable variation has proved …
nature of AUD, identifying genetic variants that comprise this heritable variation has proved …
[HTML][HTML] Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations
Alcohol consumption level and alcohol use disorder (AUD) diagnosis are moderately
heritable traits. We conduct genome-wide association studies of these traits using …
heritable traits. We conduct genome-wide association studies of these traits using …
Overview of the genetics of alcohol use disorder
EA Tawa, SD Hall, FW Lohoff - Alcohol and alcoholism, 2016 - academic.oup.com
Abstract Aims Alcohol Use Disorder (AUD) is a chronic psychiatric illness characterized by
harmful drinking patterns leading to negative emotional, physical, and social ramifications …
harmful drinking patterns leading to negative emotional, physical, and social ramifications …
Genome‐wide association discoveries of alcohol dependence
Objective To report the genome‐wide significant and/or replicable risk variants for alcohol
dependence and explore their potential biological functions. Methods We searched in …
dependence and explore their potential biological functions. Methods We searched in …
Common biological networks underlie genetic risk for alcoholism in African‐and European‐American populations
Alcohol dependence (AD) is a heritable substance addiction with adverse physical and
psychological consequences, representing a major health and economic burden on …
psychological consequences, representing a major health and economic burden on …
Alcohol dependence genetics: lessons learned from genome‐wide association studies (GWAS) and post‐GWAS analyses
AB Hart, HR Kranzler - Alcoholism: clinical and experimental …, 2015 - Wiley Online Library
Background Alcohol dependence (AD) is a complex psychiatric disorder and a significant
public health problem. Twin and family‐based studies have consistently estimated its …
public health problem. Twin and family‐based studies have consistently estimated its …
[PDF][PDF] Integrating GWASs and human protein interaction networks identifies a gene subnetwork underlying alcohol dependence
Despite a significant genetic contribution to alcohol dependence (AD), few AD-risk genes
have been identified to date. In the current study, we aimed to integrate genome-wide …
have been identified to date. In the current study, we aimed to integrate genome-wide …