[HTML][HTML] Allele-specific expression and high-throughput reporter assay reveal functional genetic variants associated with alcohol use disorders

X Rao, KS Thapa, AB Chen, H Lin, H Gao… - Molecular …, 2021 - nature.com
Genome-wide association studies (GWAS) of complex traits, such as alcohol use disorders
(AUD), usually identify variants in non-coding regions and cannot by themselves distinguish …

Identification of functional genetic variants associated with alcohol dependence and related phenotypes using a high‐throughput assay

KS Thapa, AB Chen, D Lai, X Xuei… - Alcoholism: Clinical …, 2020 - Wiley Online Library
Background Genome‐wide association studies (GWAS) of alcohol dependence (AD) and
related phenotypes have identified multiple loci, but the functional variants underlying the …

Genetic underpinnings of the transition from alcohol consumption to alcohol use disorder: shared and unique genetic architectures in a cross-ancestry sample

RL Kember, R Vickers-Smith, H Zhou… - American journal of …, 2023 - Am Psychiatric Assoc
Objective: Recent genome-wide association studies (GWASs) of alcohol-related phenotypes
have uncovered key differences in the underlying genetic architectures of alcohol …

Beyond genome‐wide significance: integrative approaches to the interpretation and extension of GWAS findings for alcohol use disorder

JE Salvatore, S Han, SP Farris, KM Mignogna… - Addiction …, 2019 - Wiley Online Library
Alcohol use disorder (AUD) is a heritable complex behavior. Due to the highly polygenic
nature of AUD, identifying genetic variants that comprise this heritable variation has proved …

[HTML][HTML] Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations

HR Kranzler, H Zhou, RL Kember… - Nature …, 2019 - nature.com
Alcohol consumption level and alcohol use disorder (AUD) diagnosis are moderately
heritable traits. We conduct genome-wide association studies of these traits using …

Overview of the genetics of alcohol use disorder

EA Tawa, SD Hall, FW Lohoff - Alcohol and alcoholism, 2016 - academic.oup.com
Abstract Aims Alcohol Use Disorder (AUD) is a chronic psychiatric illness characterized by
harmful drinking patterns leading to negative emotional, physical, and social ramifications …

Genome‐wide association discoveries of alcohol dependence

L Zuo, L Lu, Y Tan, X Pan, Y Cai… - … American journal on …, 2014 - Wiley Online Library
Objective To report the genome‐wide significant and/or replicable risk variants for alcohol
dependence and explore their potential biological functions. Methods We searched in …

Common biological networks underlie genetic risk for alcoholism in African‐and European‐American populations

MZ Kos, J Yan, DM Dick, A Agrawal… - Genes, Brain and …, 2013 - Wiley Online Library
Alcohol dependence (AD) is a heritable substance addiction with adverse physical and
psychological consequences, representing a major health and economic burden on …

Alcohol dependence genetics: lessons learned from genome‐wide association studies (GWAS) and post‐GWAS analyses

AB Hart, HR Kranzler - Alcoholism: clinical and experimental …, 2015 - Wiley Online Library
Background Alcohol dependence (AD) is a complex psychiatric disorder and a significant
public health problem. Twin and family‐based studies have consistently estimated its …

[PDF][PDF] Integrating GWASs and human protein interaction networks identifies a gene subnetwork underlying alcohol dependence

S Han, BZ Yang, HR Kranzler, X Liu, H Zhao… - The American Journal of …, 2013 - cell.com
Despite a significant genetic contribution to alcohol dependence (AD), few AD-risk genes
have been identified to date. In the current study, we aimed to integrate genome-wide …