[HTML][HTML] Prospects for advancing tuberculosis control efforts through novel therapies

JA Salomon, JO Lloyd-Smith, WM Getz, S Resch… - PLoS …, 2006 - journals.plos.org
Background Development of new, effective, and affordable tuberculosis (TB) therapies has
been identified as a critical priority for global TB control. As new candidates emerge from the …

[HTML][HTML] Confronting the scientific obstacles to global control of tuberculosis

DB Young, MD Perkins, K Duncan… - The Journal of clinical …, 2008 - Am Soc Clin Investig
Tuberculosis (TB) is a major threat to global health, recently exacerbated by the emergence
of highly drug-resistant forms of the disease-causing pathogen and synergy with HIV/AIDS …

More tailored approaches to tuberculosis treatment and prevention

CM Bark, WH Boom, JJ Furin - Annual Review of Medicine, 2024 - annualreviews.org
Recent advances in the treatment of tuberculosis (TB) have led to improvements
unprecedented in our lifetime. Decades of research in developing new drugs, especially for …

[HTML][HTML] Priority-setting for novel drug regimens to treat tuberculosis: an epidemiologic model

EA Kendall, S Shrestha, T Cohen, E Nuermberger… - PLoS …, 2017 - journals.plos.org
Background Novel drug regimens are needed for tuberculosis (TB) treatment. New regimens
aim to improve on characteristics such as duration, efficacy, and safety profile, but no single …

[HTML][HTML] Tuberculosis: Past, present and future of the treatment and drug discovery research

AD Bendre, PJ Peters, J Kumar - Current research in pharmacology and …, 2021 - Elsevier
Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium
tuberculosis. Despite decades of research driving advancements in drug development and …

[HTML][HTML] Advances in diagnostics and drug discovery against resistant and latent tuberculosis infection

C Shleider Carnero Canales, J Marquez Cazorla… - Pharmaceutics, 2023 - mdpi.com
Latent tuberculosis infection (LTBI) represents a subclinical, asymptomatic mycobacterial
state affecting approximately 25% of the global population. The substantial prevalence of …

[HTML][HTML] Population-level impact of shorter-course regimens for tuberculosis: a model-based analysis

MO Fofana, GM Knight, GB Gomez, RG White… - PloS one, 2014 - journals.plos.org
Despite current control efforts, global tuberculosis (TB) incidence is decreasing slowly. New
regimens that can shorten treatment hold promise for improving treatment completion and …

New initiative speeds tuberculosis drug development: novel drug regimens become possible in years, not decades

M Spigelman, R Woosley… - The international journal …, 2010 - ingentaconnect.com
NEW TOOLS to improve the treatment and control of tuberculosis (TB) are a critical
component of any comprehensive strategy to eradicate the global TB epidemic. In particular …

Recent advances in the treatment of tuberculosis

I Motta, M Boeree, D Chesov, K Dheda… - Clinical Microbiology …, 2023 - Elsevier
Background Tuberculosis (TB) is a global health challenge and one of the leading causes of
death worldwide. In the last decade, the TB treatment landscape has dramatically changed …

Tuberculosis 2015: burden, challenges and strategy for control and elimination

M Raviglione, G Sulis - Infectious disease reports, 2016 - mdpi.com
Tuberculosis (TB) is a leading cause of morbidity and mortality worldwide, accounting for
about 9.6 million new cases and 1.5 million deaths annually. The poorest and socially …