In this review I shall describe work carried out, in collaboration with my colleagues in
Southampton, correlating knowledge of gonococcal structure with an understanding of the …

The molecular mechanisms used by the gonococcus to initiate infection exhibit gender
specificity. The clinical presentations of disease are also strikingly different upon comparison …

Gonococcal adherence to human host epithelial surfaces appears to be an important feature
in pathogenesis of gonorrhea. Attaining and maintaining close association with epithelial …

The bacterial pathogen Neisseria gonorrhoeae (gonococcus) is able to colonize and
penetrate the human mucosa, to avoid the host's defences and to persist in various …

Neisseria gonorrhoeae is the causative agent of the sexually transmitted disease
gonorrhoea. Gonorrhoea has been recorded in man throughout the medieval and modern …

The pathogenesis of any infectious disease may be considered to comprise a series of
events, each of which may determine not only the success of the infection, but also the …

As will be seen in other papers in this volume, some of the initial events of the colonization of
the human host by Neisseria gonorrhoeae are being clearly defined. Gonococcal pili play a …

The relative virulence of isogenic clones of colony type 1 (TI)(piliated) and colony type 4
(T4)(nonpiliated) gonococci was assessed in organ cultures of human fallopian tubes. The …

Gonococci of the colonial types that are associated with virulence, types 1 and 2, have pili
that enable the bacteria both to attach in vitro to human epithelial cells and to resist …

In men with gonococcal urethritis, the urethral epithelial cell is a site of infection. To study the
pathogenesis of gonorrhea in this cell type, we have developed a method to culture primary …