The crosstalk between the renin-angiotensin system and Adenosine monophosphate-
activated protein kinase (AMPK) gained significant interest due to their involvement in the …

Abstract Angiotensin II (Ang II), the effector of the renin-angiotensin system (RAS), is a key
player in the pathogenesis of chronic hypertension, accompanied by vascular tissue …

BACKGROUND Baicalein, a specific lipoxygenase (LOX) inhibitor, has anti-inflammatory
and antioxidant effects. However, the functional role of baicalein in angiotensin II (Ang II) …

Baicalin, a flavonoid glycoside from Scutellaria baicalensis Georgi., exerts anti-hypertensive
effects. The present study aimed to assess the cardioprotective role of baicalin and explore …

Introduction: An excess of angiotensin II (Ang II) causes hypertension and vascular injury.
Activation of mitogen-activated protein kinase p38 (p38-MAPK) plays a substantial role in …

Highlights•Paeoniflorin was first investigated to improve cardiac remodeling by modulating
MAPK pathway.•Cardiac remodeling was measured in different forms, including cardiac …

Background/Aims: Endothelial-to-mesenchymal transition (EndMT) is a mechanism that
promotes cardiac fibrosis induced by Angiotensin II (AngII). Kaempferol (KAE) is a monomer …

Ventricular remodeling is associated with many heart diseases, and ventricular remodeling
induced by hypertension can be fatal independent of hypertension. In this study, we …

The early myocardial response of hypertension is an elevation of angiotensin‐II (Ang‐II)
concentration, leading to heart failure and cardiac hypertrophy. This hypertrophic event of …

Hypertension induced hypertrophy and diastolic dysfunction and is associated with cardiac
oxidation and reduced NO production. We hypothesized that tetrahydrobiopterin (BH4) can …