Eating disorders are a group of disease states including anorexia nervosa, bulimia nervosa
and binge eating on one end as well as episodic or chronic overeating resulting in obesity at …

Leptin is an adipocyte-secreted hormone the serum levels of which reflect the amount of
energy stored in adipose tissue as well as short-term energy imbalance. Serum levels of …

Since its discovery, leptin (a 167‐amino acid product of the OB gene) has quickly moved to
the forefront as an important hormone for regulation of energy balance. It closes a feedback …

The discovery of leptin has enhanced understanding of the interrelationship between
adipose energy stores and neuronal circuits in the brain involved in energy balance and …

Historically, adipose tissue was considered to be a passive storage vessel discharging
nutrients in times of famine and accumulating fat in times of surfeit. This view changed with …

Leptin is an adipocyte-derived hormone, which is involved predominantly in the long-term
regulation of body weight and energy balance by acting as a hunger suppressant signal to …

Leptin, discovered through positional cloning 15 years ago, is an adipocyte-secreted
hormone with pleiotropic effects in the physiology and pathophysiology of energy …

Cloned in 1994, the ob gene encodes the protein hormone leptin, which is produced and
secreted by white adipose tissue. Since its discovery, leptin has been found to have …

Unravelling the diverse hormonal and neuroendocrine systems which regulate energy
balance and body fat has been a long-standing challenge in biology, with obesity as an …

The adipocyte-derived hormone, leptin, regulates food intake and systemic fuel metabolism;
ob/ob mice, which lack functional leptin, exhibit an obesity syndrome that is similar to morbid …