Leptin is a hormone discovered almost 30 years ago with important implications in
metabolism. It is primarily produced by white adipose tissue (WAT) in proportion to the …

Obesity results from an abnormal accumulation of fat in the white adipose tissue. Recent
research utilizing genetic models of obesity in rodents has implicated a major role of leptin …

Leptin is a hormone primarily produced by the adipose tissue in proportion to the size of fat
stores, with a primary function in the control of lipid reserves. Besides adipose tissue, leptin …

This paper reviews the general mechanisms by which leptin acts as a regulator of lipid
reserves through changes in food intake, energy expenditure and fuel selection, with an …

Metabolic syndrome poses a major threat on human health affecting the quality of life.
Adipose tissue is an important organ which plays a crucial role in the pathogenesis of …

Leptin, a protein containing 167 amino acids, demonstrates structural similarities with
cytokine family and is mainly produced by adipocytes. The leptin receptor (OB-R) is a large …

The discovery of leptin was intrinsically associated with its ability to regulate body weight.
However, the effects of leptin are more far-reaching and include profound glucose-lowering …

In recent years, the adipose tissue has emerged as an important endocrine organ. It is now
recognized that besides storing energy the adipocytes also secrete several bioactive …

Leptin is a mainly adipocyte-secreted protein that was discovered 5 years ago. Most of the
research following this discovery focused on the role of leptin in body weight regulation …

Leptin is a master regulator of energy balance and body adiposity. Additionally, leptin exerts
important control on glucose homeostasis, thermogenesis, autonomic nervous system and …