Feeding is essential for animal survival and reproduction and is regulated by both internal
states and external stimuli. However, little is known about how internal states influence the …

Sensing satiety is a crucial survival skill for all animal species including human. Despite the
discovery of numerous neuromodulators that regulate food intake in Drosophila, the …

Behavior and physiology are orchestrated by neuropeptides acting as central
neuromodulators and circulating hormones. An outstanding question is how these …

Regulation of meal size and assessing the nutritional value of food are two important
aspects of feeding behavior. The mechanisms that regulate these two aspects have not …

Feeding is a fundamental activity of all animals that can be regulated by internal energy
status or external sensory signals. We have characterized a zinc finger transcription factor …

Neuropeptides are the most diverse messenger molecules in metazoans and are involved in
regulation of daily physiology and a wide array of behaviors. Some neuropeptides and their …

The fly pharyngeal sense organs lie at the transition between external and internal nutrient-
sensing mechanisms. Here we investigate the function of pharyngeal sweet gustatory …

Perceived palatability of food controls caloric intake. Sweet taste is the primary means of
detecting the carbohydrate content of food. Surprisingly, sweet taste sensitivity is responsive …

Sucrose is an attractive feeding substance and a positive reinforcer for Drosophila. But
Drosophila females have been shown to robustly reject a sucrose-containing option for egg …

In the fruitfly Drosophila melanogaster, hunger has a significant impact on its sensory
systems and brain functions, and consequently modifies related behaviors. However, it …