Bitter taste receptors (T2Rs) are G protein-coupled receptors (GPCRs) expressed in various
cell types including ciliated airway epithelial cells and macrophages. T2Rs in these two …

Introduction Bitter taste receptors (T2Rs) are G protein-coupled receptors identified on the
tongue but expressed all over the body, including in airway cilia and macrophages, where …

Background Bitter taste receptors (T2R) have recently been demonstrated to contribute to
sinonasal innate immunity. One T2R, T2R38, regulates mucosal defense against gram …

Bitter taste receptors (T2Rs) are GPCRs involved in detection of bitter compounds by type 2
taste cells of the tongue, but are also expressed in other tissues throughout the body …

Bitter taste receptors (taste family 2 bitter receptor proteins; T2Rs), discovered in many
tissues outside the tongue, have recently become potential therapeutic targets. We have …

We previously observed that the human bitter taste receptor T2R38 is an important
component of upper respiratory innate defense because it detects acyl homoserine lactone …

Bitter taste receptors (T2Rs) localize to airway motile cilia and initiate innate immune
responses in retaliation to bacterial quorum sensing molecules. Activation of cilia T2Rs …

Bitter taste receptors (T2Rs) in the human airway detect harmful compounds, including
secreted bacterial products. Here, using human primary sinonasal air-liquid interface …

Taste receptors on the tongue communicate information to the brain about the nutrient
content or potential toxicity of ingested foods. However, recent research has now shown that …

Objective Chronic rhinosinusitis (CRS) refractory to therapeutic intervention may involve a
particularly resistant infection known as a bacterial biofilm. Critical to biofilm formation is the …