Background Bitter (T2R) and sweet (T1R) taste receptors in the airway are important in
innate immune defense, and variations in taste receptor functionality in one T2R (T2R38) …

The receptors involved in bitter taste perception (bitter taste receptors—T2Rs) constitute a
family of G-protein-coupled receptors, of which around 29 subtypes have been identified in …

Bitter taste receptors (T2Rs) are a group of 25 chemosensory receptors expressed at
significant levels in the human airways. In human airways, bitter taste receptor 14 (T2R14) …

Taste receptors, first identified on the tongue, are best known for their role in guiding our
dietary preferences. The expression of taste receptors for umami, sweet, and bitter have …

Constant exposure of the airways to inhaled pathogens requires efficient early immune
responses protecting against infections. How bacteria on the epithelial surface are detected …

Background Bitter-taste receptors (TAS2Rs) are involved in airway relaxation but are also
expressed in human blood leukocytes. We studied TAS2R expression and the effects of …

Background It is not fully understood how sinonasal epithelial cells detect the presence of
pathogens and activate innate defense responses necessary for protecting the upper airway …

Over the past several years, taste receptors have emerged as key players in the regulation
of innate immune defenses in the mammalian respiratory tract. Several cell types in the …

Taste receptors, initially identified in the oral epithelium, have since been shown to be
widely distributed, being found in the upper and lower respiratory tracts, gastrointestinal …

The bitter taste receptors (T2Rs) expressed in human sinonasal mucosae are known to elicit
innate immune responses involving the release of nitric oxide (NO). We investigated the …